專利名稱：一類人類肝臟相關(guān)基因的制作方法
技術(shù)領(lǐng)域：
本發(fā)明涉及生物技術(shù)領(lǐng)域，具體地，涉及一類基因，尤其涉及一類人類肝臟相關(guān)基因。
背景技術(shù)：
肝臟是人體內(nèi)最大的消化腺。也是體內(nèi)新陳代謝的中心站。據(jù)估計(jì)，在肝臟中發(fā)生的化學(xué)反應(yīng)有500種以上，實(shí)驗(yàn)證明，動(dòng)物在完全摘除肝臟后即使給予相應(yīng)的治療，最多也只能生存50多個(gè)小時(shí)。這說明肝臟是維持生命活動(dòng)的一個(gè)必不可少的重要器官。肝臟的血流量極為豐富，約占心輸出量的1/4。每分鐘進(jìn)入肝臟的血流量為1000-1200ml。肝臟的主要功能是進(jìn)行糖的分解、貯存糖原；參與蛋白質(zhì)、脂肪、維生素、激素的代謝；解毒；分泌膽汁；吞噬、防御機(jī)能；制造凝血因子；調(diào)節(jié)血容量及水電解質(zhì)平衡；產(chǎn)生熱量等。在胚胎時(shí)期肝臟還有造血功能。
肝臟疫病分為肝炎、肝硬化、脂肪肝、肝癌等。現(xiàn)代醫(yī)學(xué)實(shí)驗(yàn)證明，肝病病毒侵入人體后，并不直接引起肝細(xì)胞的損害，只是在肝細(xì)胞內(nèi)吸收營(yíng)養(yǎng)賴以生存，并在肝細(xì)胞內(nèi)復(fù)制、繁殖。其復(fù)制病毒的“零部件”如表面抗原(HBsAg)、e抗原(HBeAg)釋放在肝細(xì)胞膜上，引起人體免疫系統(tǒng)對(duì)這些抗原物質(zhì)產(chǎn)生免疫反應(yīng)，這種反應(yīng)造成肝細(xì)胞的損傷、壞死。免疫反應(yīng)的強(qiáng)弱決定于肝臟受損程度及臨床癥狀輕重。這場(chǎng)由病毒引發(fā)的、免疫系統(tǒng)對(duì)肝細(xì)胞的戰(zhàn)爭(zhēng)，使大約25％的患者的肝臟成為戰(zhàn)火連綿的戰(zhàn)場(chǎng)，肝臟的損傷由此加重。肝病的危害絕不僅僅限于肝臟本身，它還可以引起其它多種疾病。常見的有(1)糖尿??；(2)胰腺炎；(3)膽道感染；(4)功能性腎衰竭；(5)膽汗性腎??；(6)腎小球腎炎；(7)腎小管酸中毒；(8)溶血性貧血；(9)再生障礙性貧血；(10)心肌炎和心包炎；(11)結(jié)節(jié)性動(dòng)脈炎；(12)消化性潰瘍；(13)自發(fā)性腹膜炎；(14)性激素代謝紊亂；(15)甲狀腺功能改變；(16)肝性骨病，等等。肝病不僅對(duì)患者的身體甚至生命造成危害，而且對(duì)患者心理上的打擊也是十分沉重的。無論是肝病患者還是病毒攜帶者，在生活、社交、求職、升學(xué)等方面都會(huì)受到嚴(yán)重影響。
生物基因組中可轉(zhuǎn)錄表達(dá)的序列(即基因)僅占總序列的3-5％，對(duì)這部分序列進(jìn)行測(cè)定，將直接導(dǎo)致新基因的發(fā)現(xiàn)，并獲取基因組中與產(chǎn)業(yè)化關(guān)系最為密切的信息。
人類肝臟相關(guān)基因是指在人類肝臟中表達(dá)的相關(guān)基因，其與一些肝臟疾病相關(guān)，因此，研究人類肝臟相關(guān)基因?qū)μ剿鞲闻K疾病的發(fā)病機(jī)理及研制肝病的治療藥物具有重要意義。

發(fā)明內(nèi)容
本發(fā)明要解決的技術(shù)問題是提供一類人類肝臟相關(guān)基因。
本發(fā)明要解決的技術(shù)問題通過如下技術(shù)方案實(shí)現(xiàn)本發(fā)明提供一類人類肝臟相關(guān)基因，其包括以下序列的基因(a)SEQ ID No.1～SEQ ID No.30所示的序列；(b)SEQ ID No.1～SEQ ID No.30所示的序列中每條序列的互補(bǔ)序列；(c)與SEQ ID No.1～SEQ ID No.30所示的序列中每條序列有至少70％同源性的序列，及(d)上述(a)～(c)中一條或數(shù)條的組合。
較佳地，所述序列包括具有SEQ ID No.1～SEQ ID No.30所示的序列。
本發(fā)明還提供了一種探針分子，所述的探針分子含有上述序列中約8-100個(gè)連續(xù)的核苷酸。
本發(fā)明的人類肝臟相關(guān)基因，在研究肝臟疾病的致病機(jī)理以及開發(fā)治療肝臟疾病的藥物中發(fā)揮重要作用。
具體實(shí)施例方式
下面結(jié)合具體實(shí)施例，進(jìn)一步闡述本發(fā)明。應(yīng)理解，這些實(shí)施例僅用于說明本發(fā)明而不是限制本發(fā)明的范圍。下列實(shí)施例中未注明具體條件的實(shí)驗(yàn)方法，通常按照常規(guī)條件如Sambrook等人，分子克隆實(shí)驗(yàn)室手冊(cè)(New YorkCold Spring HarborLaboratory Press，1989)中所述的條件，或按照制造廠商所建議的條件。
實(shí)施例1人肝臟組織的mRNA的分離組織分離(Tissue isolation)肝臟來源于5個(gè)成年男性，在肝臟切除手術(shù)后，將肝臟組織立即置于液氮中冷凍保存。
mRNA的分離(mRNA isolation)取出肝臟組織，用研缽研碎，加入盛有裂解液的50ml管，充分振蕩后，再移入玻璃勻漿器內(nèi)，勻漿后移至50ml新管，抽提總RNA(TRIzol Reagents，Gibco，NY，USA)。用甲醛變性膠電泳鑒定總RNA質(zhì)量。用帶Oligod(T)的纖維素柱分離總RNA中的mRNA，定量。
實(shí)施例2cDNA文庫的構(gòu)建(Constuction of cDNA library)以mRNA為模板，合成雙鏈cDNA。補(bǔ)平末端后，加含EcoRI切點(diǎn)的接頭。磷酸化EcoRI末端后，用XhoI限制性內(nèi)切酶消化1.5小時(shí)，再進(jìn)行片斷分離。過柱篩選長(zhǎng)度＞500bp的片段，用酚-氯仿抽提，乙醇沉淀，無菌水溶解，連接至Uni-ZAP XR載體(Strategene，CA9203，USA)，以ZAP-cDNA Gigapack III Gold Cloning Kit(Strategene，CA9203，USA)進(jìn)行包裝，宿主菌使用XL 1 Blue MRF’(Strategene，CA9203，USA)細(xì)菌。涂板并測(cè)定滴度。
實(shí)施例3測(cè)序及數(shù)據(jù)庫建立(Seqencing and Database Constructing)挑選文庫中有外源片段插入的克隆，擴(kuò)增后抽提質(zhì)粒(Qiagen Germany)，用T3和T7作為3’和5’端的通用引物，采用終止物熒光標(biāo)記(Big-Dye，Perkin-Elmer，USA)的方法，在ABI 377測(cè)序儀(Perkin-Elmer，USA)上進(jìn)行EST大規(guī)模測(cè)序。測(cè)序結(jié)果用FACTURA軟件去除載體序列，傳輸?shù)絊UN Ultra 450Server上進(jìn)行下一步的處理。所有的序列信息再用GCG軟件包(Wisconsin group，USA)中的BLAST和FASTA軟件搜索已有的數(shù)據(jù)庫(Genebank+EMBL)，將無同源性或同源性低于95％的序列視為新基因建立數(shù)據(jù)庫。
實(shí)施例4基因的全長(zhǎng)克隆(Cloning of Full-length cDNA)在得到的新基因片段序列信息基礎(chǔ)上，進(jìn)行cDNA全長(zhǎng)克隆，分兩階段進(jìn)行(1)“電子克隆”(Electronic Cloning)以新基因片段序列作為探針?biāo)褜bEST數(shù)據(jù)庫，將重疊序列＞50bp，同源性在98％以上的表達(dá)序列標(biāo)簽(Expressed Sequence Tag，簡(jiǎn)稱“EST”)序列認(rèn)為同一序列(Consensus Sequence)，取出并用AUTOASSEMBLER軟件進(jìn)行連接，部分EST可以延伸探針序列。再用STRIDER軟件分析被延伸的序列是否具有完整的開放閱讀框架(OpenReading Frame，ORF)，用BLAST搜尋Genbank或SwissProt以確定該序列的核苷酸和氨基酸水平上是否與其他物種有同源性，以幫助判別所得到的基因全長(zhǎng)完整性如何。通過電子克隆的方法，通?？色@取人肝臟相關(guān)基因的全長(zhǎng)序列。
(2)cDNA末端快速擴(kuò)增(Rapid Amplification of cDNA Ends，RACE)如果通過“電子克隆”方法仍未得到完整的cDNA全長(zhǎng)，則在已有序列5’或3’端設(shè)計(jì)引物，在人類肝臟Marathon-Ready cDNA文庫(Clontech Lab，Inc，USA)中進(jìn)行長(zhǎng)距離PCR反應(yīng)。然后對(duì)PCR產(chǎn)物克隆、測(cè)序。用AUTOASSEMBLER及STRIDER軟件分析被延長(zhǎng)的序列有無完整的ORF，如無，重復(fù)上述過程直至獲得全長(zhǎng)。
(3)RT-PCR對(duì)于5’和3’端的已知的序列，如果中間有一段間隙(gap)無法從已有的公共數(shù)據(jù)庫或自身數(shù)據(jù)庫獲得，可考慮采用RT-PCR的方法。在序列5’端設(shè)計(jì)引物，3’端引物采用Oligo-dT，在肝臟總RNA庫中進(jìn)行擴(kuò)增。然后對(duì)產(chǎn)物進(jìn)行克隆、測(cè)序。最后拼接便獲得全長(zhǎng)。
通過組合使用上述3種方法，可獲得人肝臟相關(guān)蛋白的全長(zhǎng)編碼序列。
序列表<110>上海人類基因組研究中心<120>一類人類肝臟相關(guān)基因(8)<130>NP-10158<160>30<210>1<211>1717<212>DNA<213>Homo sapiens<400>11 gcaattcact ttggattttc taatatccca tttctgagaa gaatggcaga ctattgaaca61 ggtgtatttt aggtcacgtg gggactgcat ccacctgaaa atccaccgtt gacttatcag121 gaaactcaga gatcaggatc tttcacagag tagtctttta agaagattca gttgtcaaca181 gctagcagtc tctttgccaa ataattatat ctgtgacttc tgaaactatt tggctgccta241 aagttaaagg acttggggaa agtccttcca ctgctcttct gcagtagtgt cacaccactc301 agtgcagggc ccaccaagaa gaaagcagtg tcaggatcca catggcacta tggtaacttt361 gtgaaagggg acattttctc cctctgaact tctcttcata aagtcattgt gcttcctctt421 ggggatcacc tgttcagtct caatgggctt tgatgtgctc ctggatcaag tgggtggcat481 ggggagattc cagatttgtc tgatagcttt cttttgcatc accaacatcc tactgttccc541 taatattgtg ttggagaact tcactgcatt cacccctagt catcgctgct gggtccccct601 cctggacaat gacagtgtgt ctgacaatga taccgggacc ctcagcaagg atgacctcct661 gagaatctcc atcccactgg actcaaacct gaggccacag aagtgtcagc gctttatcca721 tccccagtgg cagctccttc acctgaacgg gaccttcccc aacacaaatg agccagacac781 ggagccctgt gtggatggct gggtgtacga cagaagctct ttcctctcca ccatcgtgac841 tgagtgggac ctggtatgtg aatctcagtc actaaaatca atggttcaat ccctatttat901 ggctgggtca ctgctgggag gtctaatata tggccatctt tcagacaggg ttggacggaa961 gatcatatgc aaattgtgtt tcctccagct ggccatctct aacacctgtg cggccttcgc1021 tcccaccttc cttgtttact gcatactgcg cttcttggca gggttctcca ccatgactat1081 tttgggaaac acttttattc tcagcttaga gtggacattg ccccggtcac gatctatgac1141 aataatggtg ctattatgtt cctacagtgt tgggcagatg ctcctaggag ggctggcttt1201 tgccattcag gactggcaca tattgcaact gactgtgtct acacccataa ttgtcctctt1261 cttgtcctct tggtatgaac aatctccaca ttctttgcct gtaagcgagg ctatggtaga1321 catagaaagg aaaattgtga cacctgggat ctgttcggtc tctggcctag tcctgagcca1381 tgatgtccat agtacctatt gtgtcacctg agaagcaaac aatggaatag gatgacacta1441 tatgtgggga ggctggcact ttgcattcat tattttagac atggaattat catgaaatta1501 tttttcttaa tagaaaaaat acccacttat ttttgaagca aatgtattat ttatctaact
1561 tttggaatat tatgtgatgg agataatttg ggggcttttg tcattgtaac tgagattgaa1621 tataaggaaa acacaataaa tttatctaca taactattta aaaaaaaaaa aaaaaaaaaa1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa<210>2<211>2795<212>DNA<213>Homo sapiens<400>21 attttcgatt ccactctctt ccgtttctgt cgctgcagtc gtccgcggga ctccggccgg61 ttgccggccc caggcggtgc ttctccccac caccgcccag ctcagctcag cccagcccag121 cccactctgc ccttagaggc ccttctcccc aaagacgcac tccagaagtc tcgccctcgt181 gcggctgagg agcctgggat cccagacctg aacaagtgaa acccccgccc ctgaagaatg241 ggtaagacgt tttcccagct gggctcttgg cgggaggatg agaacaagtc aatcctgtcc301 tccaaaccag ccattggcag caaggctgtc aactactcca gcaccggtag cagcaagtct361 ttttgttcct gtgtgccttg tgaaggaact gctgatgcca gcttcgtgac ttgtcccacc421 tgccagggca gtggcaagat tccccaagag ctggagaagc agttggtggc tctcattccc481 tatggggacc agaggctgaa gcccaagcac acgaagctct ttgtgttcct ggccgtgctc541 atctgcctgg tgacctcctc cttcatcgtc tttttcctgt ttccccggtc cgtcattgtg601 cagcctgcag gcctcaactc ctccacagtg gcctttgatg aggctgatat ctacctcaac661 ataacgaata tcttaaacat ctccaatggc aactactacc ccattatggt gacacagctg721 accctcgagg ttctgcacct gtccctcgtg gtggggcagg tttccaacaa ccttctccta781 cacattggcc ctttggccag tgaacagatg ttttacgcag tagctaccaa gatacgggat841 gaaaacacat acaaaatctg tacctggctg gaaatcaaag tccaccatgt gcttttgcac901 atccagggca ccctgacctg ttcatacctg agccattcag agcagctggt ctttcagagc961 tatgaatatg tggactgccg aggaaacgca tctgtgcccc accagctgac ccctcaccca1021 ccatgacctg tctgctgtcc ctgtactcca ggcacctgca accctggtct atatctccca1081 caactccctg gtgactaagg aaggactaca gaggctttgc caaaggagaa gccctgcctc1141 atcacaccct tacctcccac cccctcagca caggaagctt gctttgaagt taacttcata1201 cacacacact catatcctcc agtttccccc agattctttc aggggctgcc atcagattct1261 gcccttggtt agttttttgt tttttttttg gtagagacag agtctcactg ttggtccagg1321 ttggttttga actcctgggc tcaagcgatc ctcccttctt ggcctcccaa agcacttgga1381 ttacagatgt gagcctgtgc ctggctggtc tttcttgagg aaaatctgac ctggcatttt1441 cttgaggcac cttagattcc ctggagtggc acctggcctt tctgtactga gcacctggtc1501 agtctgaagg gggcatttca ccccagctcc atcagggctg gcagtcccgt ctgaatgtgg1561 agagagctgt agttttatct ggcttttaaa acatggacct gccggctggg cgcagtggct1621 tacacctgta atcccagtac tttgggaggc cgaagtgggt ggatcgcttg agggcaggag1681 ttcgtgacca gcctggtcaa catggtgaaa ccttgtctct actaaaaata caaaaattag1741 ctgggtgtgg tggcatgcgc ctgtaatccc ggctactcgg gaggctgagg cagcagaatc1801 acttgaaacc ggaaggcaga ggttgcagtg agccaagatc gtgcaactgc actccagcct1861 gggcaaaaga gcaaaacttt gtctcaaaaa aagactcttt tcaagttttc taccctctga1921 taagaaaatt tggggatatc cagtgccatc tccaaggact ttcaggggat catagatgct
1981 tttctgtgcc tatctgcttt gaccatgtga aaaagtgata gtctgcttct ctctggtaac2041 ttgtctgcca cccatctgat agtaagatta gccaaggccc tttagccctc tgtcctttct2101 ggttattgac tgtccctggt tcctaggaag acagagttgt tctccagcta aagcgtctcc2161 tctctataaa gtagttttac tattcttttc atagcaggag ccaaaatagt agaggagggg2221 agagaggcac ctggcactct gcgggcctgc acaggaaaaa cagagccaaa gacagaatca2281 ttgtataaga tatttattaa aggagagcct ctaagtccac atcctgagcc catgtgagtg2341 gacacaggta ggtaaaacgg tgggtccagc tgctgtcatc tgaaagcctt caggagatga2401 agctatcagt atccagctga aggctgctgg gttctgttcc accaccacct tagcaccagg2461 gccctctctg gtcccagagg cctcatctct ccttgggctt tgacaatgtg gagcagcaca2521 tcagcaggga ctggtctaga ccctcccttt cctgtcactt agctggagct aagctccaga2581 taacccctag gttcccactg gctcctagta gaaatagttt ctgtacttta gcagaacagg2641 aaggatattt gttcattaaa ggtggcttgg tcttacagct gggtgcagtg gtatatacct2701 gtagtcccag ctactcagga agctgaggtg agaggatctc tagagcccag gaattcaagt2761 ttaacatgag cagcaacatt agcaagaccc cgttt<210>3<211>2759<212>DNA<213>Homo sapiens<400>31 ggcaggggcg cggcgccggc tggggccccg tcttgggtgt ccacgccgtc gcctgaccgt61 tcgagggttt gatcgccagc gcagcctcgc cctgcccaga cagctgggcc ctaaggggat121 agccagcgcc tttagactta tcttaaatcg ggcatcggca tcaacactta tttctggggt181 cctccatgga aagcagctcc cgaaacaaca cccgcccggt ccgccctccg ctgcactgga241 aaaccgcccc tggacgtttc tgccgcagtg tccccctcac ggagttccgt ttgtctgctt301 ggtcggttgt tctctggagc cccaggaccc aggccgcttg tatgtgcctg cggccgcacg361 gccccaacac gcggacttcg agcggtaccg ggagacccgc gcggcctcct cggagtggac421 agtgaagcag cagctgggct aggcagtggg gctgggcctg cccatgggga cccgtccacg481 tctccaggac atcagcctga gcctcttcgc agcctcgttt tctgttgacc gagttctgca541 aggggacgta gaggaaccac agcgttcttg cgcttgagac cgctgtgatt ttctgacatt601 ttggaggcag aaatgcctgg ggaaaggccc acagatgcaa ctgtcatccc tagtgccaaa661 agggaacgga aagcgattac ccttgacctc aaattggaag tgttacgacg atttgaagcg721 ggtgagaagc tcagtcagat cgcaaaggcc ttagatcttg ctatctctac agtggcgacc781 attcgagata gtaaagaaaa aatcaaagcg agttcacaaa tagctactcc tctgagagcc841 tctcggttga ctcgccatcg aagtgcagtg atggagagca tggagcagct gctgagcttg901 tggctggaag accagagcca gccaaatgcg accttgagcg ccgccatcgt tcaggagaag961 gctgagtttg atgacttaca gcgtgaacat ggcgaaggtt ctcaaacgga gaggtttcat1021 gcaagtcaag ggtggcttgt gagattcaag gagtgccact gtttgcccca cttcaagatg1081 aacagcgcag ctcccagcaa caaggacatg tacacagaaa tgctgaaaag catcatcgaa1141 gaaggtgagt acacccccca ggtgtcttta acgtagatga gacgagactt gattggaaga1201 gaatgcccaa aggaacgttt atttccgagg aagagaatgc tgagccaggg tttaagtcat1261 ccaaagatcg cttgatgctg ctgcttggtg gcagtgcagc tggggacttt aagttgaagc
1321 ccttactggt gtaccgctca gaaacccgca aggctctgaa gggttcttga agcccagttt1381 gcccgtgatt tggcgctcca acagaaaggc ttgggtgacc aggagcatct ttcatgaatg1441 gttcacttac tttttttgcc gttgaaaaat acagtgccca aaataatctc accaacaaag1501 cactgctcat actagacagt gcgtcatgcc actctgtaaa tttgagcgac ctttctgata1561 actaagagta gaataccttc aggccaggcg cggtggctca cgcctgtaat cccagcactt1621 tgggaggccg agacgggcgg atcacctgag gtcaggagtt cgagaccagc ctcaacatgg1681 agaaaccccg tctctactaa aaatacaaat ttagccgggc gtggtggtgc aggcctgtaa1741 tcccagctac tcgggaggct aaagcaggag aattgcttga acctgggagg cggaggttgt1801 ggtgagccga gatcgcgcca ttgcactcca tcctggacaa caggagtgaa actccgtctc1861 aaaaaaaaaa aagaaaaaaa agaagtacaa gagtataata ccttcatgac agtacagctg1921 actcaatccg gaccacgtgt caaggtgtaa tctcgacctt gaaagctcat tatctgagaa1981 ggacttttca gcacatccta gaagcagcgg atggtgagga cacagctatg atcagggaat2041 tttggagaaa ctacagcatc atggatgctg tggacatggc catcgcatgg gaggagctca2101 aaccagcact aatgaacagc atgtggaaga agatttggcc tgagtgtgtt caggcccagc2161 gtttttccca ggcagataac attgcacagc ttcaaaaaaa cattgtgacc cttgccagaa2221 atgtggcctt tgaagaggtt gctgaggctg ctgtggacca gttgctgcag tcccatgaag2281 aagatctctc aaatgaggaa ctgatgcggc tggaacagga gctggcagtg ggggaggagg2341 agagggaaga tggtccctgg gcactgtggc agctaaccac aggaagactg tcggcagccc2401 tctcacattt tgaggctggc ttgtaggtcc ttgctagtaa cagccctaat gatgactgga2461 aactgagagg ttccagagaa atcagtgttg cagtaaactg ctagcaggag ctgtacaatg2521 agaaaaagcg ccactcaaaa caactctctt aggtcatttt tcaatgtgtg taaccaaaag2581 ttaatcagaa taaagcggaa gcaccatgat gacctcaaca gtggaggccc agccaggcct2641 ccctgctctg tggtgttgga catccctgga aaccttgctg ttggtatttc cattttgata2701 cttgagagca tcaaattttg tcattaaaat gttatttaaa taaaaaaaaa aaaaaaaaa<210>4<211>1405<212>DNA<213>Homo sapiens<400>41 tgctgcggct ccgcagcggg ctgaggcact ttcgggcaac acccaatact cggggctccg61 ctcggcttct tcgcgccgag atgcctaaga aggctggtgc gacgaccaag ggtaaaagcc121 agagcaagga accagagaga ccacttcctc ccttaggtcc tgtggcagtt gatcctaaag181 gatgcgtcac catagccatc catgcaaaac ctggctccaa acaaaatgct gtaacagatt241 tgacagcaga ggctgtaaat gtagctattg cagcacctcc atcagaggga gaggctaatg301 ctgagctctg tcggtatctt tccaaggtcc tagaactcag gaagagtgat gtggttttgg361 ataagggtgg taaatctcgt gaaaaggtgg tgaagctttt ggcttctaca actccagaag421 agatcttgga gaaattaaaa aaggaagcca aaaaaacata aaagcaagaa atgaggccgg481 gcgcagtggc tcatgcctgt aatcccagca ctttgggagg ccgtggtggg cggatcacct541 gaggtcagga gttcgagacc agcctgacca acatggtgaa accccatctc tacgaaaaat601 acaaaattag ccagatgtga tggcgcatgc ctgtaatccc agttactcag gaggctgagg661 caggagaatc acttgaacct ggggggcgga ggttgcagta agccgagatc gcgccgttgc
721 actccagcct gggcaacaag agtgaaactc tctccccccg aaaaaaaaga aataaaaaat781 acatccttga gaaacttttt tattgctaat ggtgaagagg ctgttaaata gaaaaatata841 ctacatgcac agaagaacat gggggacata tatatatgta tatattcgaa taagactcca901 aaaagtagaa atttaaaaag tgctatacat tgcatcaggt tctaaaatcc caaaccccaa961 acagcctgga acatgttact ctgatttcat ggcgttgtaa aataacagag ctgggaagaa1021 tattcaagat gacctgattt aacacctttc attctgttgg ggggcctttg atttcctata1081 tccagaagtt gagagactta ctcaagattg taccatgcaa gctggcaact agaacccaaa1141 tccttggact acttgttgaa tgcagttttt ctagattgta aattaaaaat catatctcca1201 caacggttct ggaattctgg ggattgcctt ctaatccagt ttacaagtga cagaaaacct1261 gttatgctgc tttgtagtct taccttagat ttttaaatgc ttatttaaat gtaaaaaaaa1321 ttttttttta catcttttaa agactatatt taccattttg ttgaaaaagt aaagaaaaat1381 catgacttgt aattaaatgt gaatt<210>5<211>1665<212>DNA<213>Homo sapiens<400>51 cacgaggaag acgtggatgg cgggaattct cgcttctggc ctgggtgagc tagaagggag61 aagcaaggac attggagtcc ctatcaccgg ttgcctagac aacttcatgg gaaggccctt121 gggaatctga gatggagcag gcgaaccctt tacgtccaga tggcgagtcc aaaggaggtg181 ttttagctca cttggaaagg ctagagaccc aagtgagcag atcccgtaaa cagtctgaag241 agctgcagag cgtgcaggcc caggaaggtg ctcttggaac caagattcat aaactaaggc301 gtctgcgaga tgagctgagg gctgtggtgc ggcaccggcg agccagcgtg aaagcatgta361 ttgccaatgt agaacccaac caaacagtgg agatcaatga gcaagaagca ttggaagaga421 aattggaaaa tgtgaaagcc attctgcagg catatcattt tacaggcctc agtggtaaac481 tgaccagccg aggagtttgt gtctgcatca gtactgcttt tgaggggaac ctattggatt541 cctattttgt ggaccttgtc atacagaaac cactccggat acatcaccat tcagtcccag601 tcttcattcc cctggaagag atagctgcaa aatatttaca gaccaacatc cagcacttcc661 tgttcagtct ctgcgagtac ctgaatgctt actctgggag gaagtaccag gcagaccggc721 ttcagagtga ctttgcagcc ctcctgactg ggcccttgca gagaaaccca ctgtgtaact781 tgctgtcatt tacttacaaa ctggatccag ggggtcagtc cttcccgttc tgtgctagat841 tgctgtataa ggacctcaca gcaactcttc ccactgacgt caccgtgaca tgtcaaggag901 tggaagtatt atccacttca tgggaggagc aacgagcatc tcatgaaact ctgttctgta961 cgaagccctt gcatcaagtg tttgcctcat ttacaagaaa aggagaaaag ttggatatga1021 gtctggtctc ctaatagatt gttttcactg cactgggagc acatcagaga aataaatccc1081 ccctcccctg ccaggtgaaa ggaaatattg cactttctgt tctcatgact aaggggacag1141 gagttccaga agaacctttc aagatgatca ggaacaccag gacgagggcc gtctcacctc1201 actcggacca catggagacc tcccttcaaa atgggagcca tgtcctgccc caccaagccc1261 tgtctgaagt ggagcttccc cgcctgtgct ccctccacag tcccggaaag cccagcggca1321 aaggcagctt tgtcccagct ctgccaccct cctgctcaca gtggtcaggg cccctcaggg1381 gcaaggacgg cagggattgg aacgagggct ctggaaggac tgttcagccc tatgcctaag
1441 acccctatgc tggggacact acaggcacac agaggaatag cagggccacc ctcagagctc1501 acacatccac gaacaaatga aggctgagga ggtttctaaa cctaaagtcc atgagtgtgc1561 acttcaatcc aggaaggtcg ggacttcctt cagtttcaaa aaataaattc tcccttccgg1621 tttggactgt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa<210>6<211>1501<212>DNA<213>Homo sapiens<400>61 cccaagcagg tcggcggcgg cggcaggaga gcggccgggc gtcagctcct cgacccccgt61 gtcgggctag tccagcgagg cggacgggcg gcgtgggccc atggccaggc ccggcatgga121 gcggtggcgc gaccggctgg cgctggtgac gggggcctcg gggggcatcg gcgcggccgt181 ggcccgggcc ctggtccagc agggactgaa ggtggtgggc tgcgcccgca ctgtgggcaa241 catcgaggag ctggctgctg aatgtaagag tgcaggctac cccgggactt tgatccccta301 cagatgtgac ctatcaaatg aagaggacat cctctccatg ttctcagcta tccgttctca361 gcacagcggt gtagacatct gcatcaacaa tgctggcttg gcccggcctg acaccctgct421 ctcaggcagc accagtggtt ggaaggacat gttcaatgtg aacgtgctgg ccctcagcat481 ctgcacacgg gaagcctacc agtccatgaa ggagcggaat gtggacgatg ggcacatcat541 taacatcaat agcatgtctg gccaccgagt gttacccctg tctgtgaccc acttctatag601 tgccaccaag tatgccgtca ctgcgctgac agagggactg aggcaagagc ttcgggaggc661 ccagacccac atccgagcca cgtgcatctc tccaggtgtg gtggagacac aattcgcctt721 caaactccac gacaaggacc ctgagaaggc agctgccacc tatgagcaaa tgaagtgtct781 caaacccgag gatgtggccg aggctgttat ctacgtcctc agcacccccg cacacatcca841 gattggagac atccagatga ggcccacgga gcaggtgacc tagtgactgt gggagctcct901 ccttccctcc ccacccttca tggcttgcct cctgcctctg gattttaggt gttgatttct961 ggatcacggg ataccacttc ctgtccacac cccgaccagg ggctagaaaa tttgtttgag1021 atttttatat catcttgtca aattgcttca gttgtaaatg tgaaaaatgg gctggggaaa1081 ggaggtggtg tccctaattg ttttacttgt taacttgttc ttgtgcccct gggcacttgg1141 cctttgtctg ctctcagtgt cttccctttg acatgggaaa ggagttgtgg ccaaaatccc1201 catcttcttg cacctcaacg tctgtggctc agggctgggg tggcagaggg aggccttcac1261 cttatatctg tgttgttatc cagggctcca gacttcctcc tctgcctgcc ccactgcacc1321 ctctccccct tatctatctc cttctcggct ccccagccca gtcttggctt cttgtcccct1381 cctggggtca tccctccact ctgactctga ctatggcagc agaacaccag ggcctggccc1441 agtggatttc atggtgatca ttaaaaaaga aaaatcgcaa ccaaaaaaaa aaaaaaaaaa1501 a<210>7<211>1694<212>DNA<213>Homo sapiens
<400>71 caagtatttt gcttcgatga tttcacgtca tcttcaaaac aacctcatga gggctgggtc61 agttagaacc taaacaaact agagacctgg ttgcaacccc tcaggctctg ctgatgctgt121 ccccctttgt tcctgcagcg tggaccctgc cagcagccag gccatggagc tctctgatgt181 caccctcatt gagggtgtgg gtaatgaggt gatggtggtg gcaggtgtgg tggtgctgat241 tctagccttg gtcctagctt ggctctctac ctacgtagca gacagcggta gcaaccagct301 cctgggcgct attgtgtcag caggcgacac atccgtcctc cacctggggc atgtggacca361 cctggtggca ggccaaggca accccgagcc aactgaactc ccccatccat cagaggcaaa421 tacttccctg gacaagaaag ccagatgaaa ctgatctacc agggccgcct gctacaagac481 ccagcccgca cactgcgttc tctgaacatt accgacaact gtgtgattca ctgccaccgc541 tcacccccag ggtcagctgt tccaggcccc tcagcctcct tggccccctc ggccactgag601 ccacccagcc ttggtgtcaa tgtgggcagc ctcatggtgc ctgtctttgt ggtgctgttg661 ggtgtggtct ggtacttccg aatcaattac cgccaattct tcacagcacc tgccactgtc721 tccctggtgg gagtcaccgt cttcttcagc ttcctagtat ttgggatgta tggacgataa781 ggacatagga agaaaatgaa aggcatggtc tttctccttt atggcctccc cacttttcct841 ggccagagct gggcccaagg gccggggagg gaggggtgga aaggatgtga tggaaatctc901 ctccatagga cacaggaggc aagtatgcgg cctccccttc tcatccacag gagtacagat961 gtccctcccg tgcgagcaca actcaggtag aaatgaggat gtcatcttcc ttcactttta1021 gggtcctctg aaggagttca aagctgctgg ccaagctcag tggggagcct gggctctgag1081 attccctccc acctgtggtt ctgactcttc ccagtgtcct gcatgtctgc ccccagcacc1141 cagggctgcc tgcaagggca gctcagcatg gccccagcac aactccgtag ggagcctgga1201 gtatccttcc atttctcagc caaatactca tcttttgaga ctgaaatcac actggcggga1261 atgaagattg tgccagcctt ctcttatggg cacctagccg ccttcacctt cttcctctac1321 cccttagcag gaatagggtg tcctcccttc tttcaaagca ctttgcttgc attttatttt1381 atttttttaa gagtccttca tagagctcag tcaggaaggg gatggggcac caagccaagc1441 ccccagcatt gggagcggcc aggccacagc tgctgctccc gtagtcctca ggctgtaagc1501 aagagacagc actggccctt ggccagcgtc ctaccctgcc caactccaag gactgggtat1561 ggatcgctgg gccctaggct cttgcttctg gggctattgg agggtcagtg tctgtgactg1621 aataaagttc cattttgtgg tcctgcaaaa aaaaaaataa aaaaaaaaaa aaaaaaaaaa1681 aaaaaaaaaa aaaa<210>8<211>2097<212>DNA<213>Homo sapiens<400>81 ggcgcgggtt tggtggcgcg tttcagcgaa gtcgcacgtg aaggatagca gtggcctgag61 aaagacccag tcatggcagc ctccagcatc agttcaccat ggggaaagca tgtgttcaaa121 gccattctga tggtcctagt ggcccttatc ctcctccact cagcattggc ccagtcccgt181 cgagactttg caccaccagg ccaacagaag agagaagccc cagttgatgt cttgacccag241 ataggtcgat ctgtgcgagg gacactggat gcctggattg ggccagagac catgcacctg
301 gtgtcagagt cttcgtccca agtgttgtgg gccatctcat cagccatttc tgtggccttc361 tttgctctgt ctgggatcgc cgcacagctg ctgaatgcct tgggactagc tggtgattac421 ctcgcccagg gcctgaagct cagccctggc caggtccaga ccttcctgct gtggggagca481 ggggccctgg tcgtctactg gctgctgtct ctgctcctcg gcttggtctt ggccttgctg541 gggcggatcc tgtggggcct gaagcttgtc atcttcctgg ccggcttcgt ggccctgatg601 aggtcggtgc ctgacccttc cacccgggcc ctgctactcc tggccttgct gatcctctac661 gccctgctga gccggctcac tggctcccga gcctctgggg cccaactcga ggccaaggtg721 cgagggctgg aacgccaggt ggaggagctg cgctggcgcc agaggcgagc ggccaagggg781 gcccgcagtg tggaggagga gtgagccgga tgccccacac accgccagtg tcataccaaa841 gagctgagct gcttcggggc catgcagccc tcctgccagc cccctgccct tttcttgccc901 tgtctctgaa ccttcagaac attgatcctt gccgcagccc cactagccaa gagaaacaga961 gaaagaccat tccccctgcc tgtccttgcg gccctgtctt ctgaggttct ctgtctgggg1021 ttggctctct taaccctttc tctgctccca gcctgcctca ccagggaagg ttggaggggc1081 ctccctctgg cttctgcatc tgcgccagca aacatcactg ccgttggtct ctcatgactt1141 aactggcttc cctctgctgc tgccttggct tcctcctaat gctcgtgctc tcctgtcctt1201 ctgaagttgc tccttggcca aatctccagc tcccttcttg ttttcctcat cctcctaccc1261 tgtactccca ccaaaccatg gtcctttaag gcacgctcct gtcctcctca ttgcccagca1321 gtagggaggg gcaggggtaa ggggacctga ggataaaggg tggggaaaca gggtcccctg1381 aggcctgtgg gggctgcagg ggaggaggat gtaccttgtg tctctttcaa gtgccttaat1441 ccgagccagc agggccttct gcttgcctgc tgccatactg tatgtaggaa agtgttctgt1501 ggctgctttg tgtcaaaaga gcagtcactc tcagaatctt gattccccat cagccaaagc1561 aaaagatggc tgctgctttg taggcatgtg cctgcaagtg ggaccttgct gggcattata1621 tgccctgtgg gggtttcaga gaccctgaaa gaggagggag gacccgcctc cttgtctgca1681 caactgcatg cacttctctc cccatcgctc cacaacctga aaccgagaag gagttgctga1741 ccagtgccca ccccggcagc ccgggaggaa cacaggcagc tcctttccct tcacgtggtc1801 tgcagagagc agggtgagct gccagctgcc cctctccacc agggtaccct gtcttggtgg1861 ttaggggcca cttttccttt gaggctctag tggaggtgga tgtccttctc tgccaggctt1921 ggcacatgat gtgaagaata aatgcccaat tcttactgtt caggtttgat gtggaatcac1981 agctgcagtg atatatattt tttatcagtg cttggttggt tttaaataaa gtgcacgcta2041 ttttattatc ttgttctgaa taaaatgtat ttactccaaa aaaaaaaaaa aaaaaaa<210>9<211>2416<212>DNA<213>Homo sapiens<400>91 ggagtgattg cccggcagag cgcgatactc gtttgtagtt tcataaacat tgatgttggg61 tcaatcatgt tctcaatgta tttaaccatg tgtttttaaa ttttttaatt tagttatcaa121 attgagaatc tgatggtatg gcattaatca ccttgaggaa gaacctttat cgtttatctg181 attttcagat gcatagagct ctggctgctt taaaaaataa acctctaaat catgttcaca241 aggtagtcaa ggagcgtctg tgcccttggt tgtgttcacg acaacctgag cctttcgggg301 tcaaattcca tcatgcccat tgtaaaaagt ttcattcgaa aaatggaaat gaccttcatc
361 cactcggtgg accagtgttc tctcaagtat ctgactgcga caggcttgaa caaaatgtta421 aaaatgagga gagtcagatg ttttacagga gactgagcaa cttgacttca tcagaagaag481 tgctaagttt tataagcacg atggaaaccc tgcctgacac tatggcagca ggagctttac541 aacgaatttg tgaagtggaa aaaaaggatg gtgatcaagg gctgccaaaa gaaatactgg601 agaatagcat ctttcaagct ttatgctttc agtttgaaaa ggagccctca cagctgtcaa661 acactagttt agtgactgct ttgcaagctc tgattctgtt gcatgtggat cctcaaagta721 gcctgttgct gaacctggtg gcagaatgcc aaaatcgtct cagaaaaggt ggcatggaag781 ttcgcaatct ttgtattctt ggggaaagtc tgattacact gcacagttca ggttgtgtga841 cactagaact cattataaat caacttcaag gtgaaaaatt ggaaacattt accccggagg901 atattgtggc cctttataga atcttgcagg catgtactga aaaagtggat gaacaccaaa961 catttttaaa taagataaac aacttttccc tatcaatagt ttccaacctg agtcctaaat1021 tgattagcca aatgctcact gccctggtgg ttcttgatca aagtcaagca tttcctctga1081 ttataaaatt gggcaaatat gtcgtgaggc atgtcccaca tttcactaac gaggagctta1141 ggagagtctt ggaggcgttc atatattttg ggcaccatga cacatttttt acaaaagccc1201 tagagcatcg tgtagctgcg gtgtgcctca cgttggatcc tgaagttgtc tgcagggtca1261 tggagtactg cagtagagaa ctgattcttt caaaacccat cctcaatgca gtggcagaaa1321 cttttgtttg ccaaacagaa aaattttcac ctcgtcagat ttctgcgtta atggaaccat1381 ttgggaaact caattatttg ccaccaaatg cctctgcttt atttagaaag ctggaaaacg1441 tgctattcac tcatttcaat tattttccac ccaaatcatt attgaaactt cttcattcat1501 gttcacttaa tgaatgccat ccagtcaact ttctggcaaa aatattcaag cctcttttcc1561 ttcaacggct gcaaggtaaa gaatctcatt tggacacatt gagtcgggca caactgaccc1621 aacttttctt agcctcagtc ctggaatgcc ctttctataa gggtccaaaa ctccttccta1681 aatatcaagt gaagtcattt cttaccccat gctgttccct ggagacccct gtggattctc1741 agctttatag atatgtgaag attgggctga ctaacctttt aggagcaaga ttatattttg1801 ctccaaaagt gttgacaccc tattgttata caatagatgt tgaaattaaa ttagatgaag1861 aaggatttgt attgccatcc acagctaatg aagatatcca taaaaggata gcactgtgta1921 ttgatggtcc aaaaaggttt tgctccaata gcaaacactt actggggaaa gaagctatta1981 aacaaagaca cctacagtta ctcggttatc aagttgttca gatcccctat catgagattg2041 ggatgctaaa atcaagacgt gaattggtgg aatatttaca aagaaaactg ttttctcaaa2101 acactgttca ttggttgcaa gaatgaatac tgacttcaga actcaaacaa tggaagaact2161 tgcattttta tggaactcag tattaaaaga aaaatataat gtgaattagc cactttgcag2221 aatatgttct agactggtga tctgaaagca tctgtagttt tccttatact atgtatacat2281 ttattgtggt aaaatttaaa attaatttta atttaatact agtgtcatag atactttttg2341 tacatcaaac aattgatcat gtgctgtaaa ggaattcaat gaataaatgt tatttttaag2401 taaaaaaaaa aaaaaa<210>10<211>1587<212>DNA<213>Homo sapiens<400>101 gggcagagga ctgctgtttg ctgacacaat cttggtgcgt tggaagtgaa agggaagagg
61 cactggtggc tgtgctttgg gcccgagcag ccagaagcca gttgccatca cctatgacga121 ggagacagcg cctggggcag agcccagtat ggggcctagc cagggctggg ttctcaccca181 cctgtgccgc cctgccttgt tacctggaag cacagccttg gggactgagc aggccctcac241 tgtcacttta agaagggaat cagccacttt gtgctcacca cctctgggga aggtgtgaga301 ggagagaagg aagtggctgt ttggctgctg acaacatgaa gacttcctgc gatgagaaca361 gaggcacagg tgccggccct gcagccccca gaacctggac tggagggggc catggggcac421 cggaccctgg tcctgccctg ggtgctgctg accttgtgtg tcactgcggg gaccccggag481 gtgtgggttc aagttcggat ggaggccacc gagctctcgt ccttcaccat ccgttgtggg541 ttcctggggt ctggctccat ctccctggtg actgtgagct gggggggccc caacggtgct601 ggggggacca cgctggctgt gttgcaccca gaacgtggca tccggcaatg ggcccctgct661 cgccaggccc gctgggaaac ccagagcagc atctctctca tcctggaagg ctctggggcc721 agcagcccct gcgccaacac caccttctgc tgcaagtttg cgtccttccc tgagggctcc781 tgggaggcct gtgggagcct cccgcccagc tcagacccag ggctctctgc cccgccgact841 cctgccccca ttctgcgggc agacctggcc gggatcttgg gggtctcagg agtcctcctc901 tttggctgtg tctacctcct tcatctgctg cgccgacata agcaccgccc tgcccctagg961 ctccagccgt cccgcaccag cccccaggca ccgagagcac gagcatgggc accaagccag1021 gcctcccagg ctgctcttca cgtcccttat gccactatca acaccagctg ccgcccagct1081 actttggaca cagctcaccc ccatgggggg ccgtcctggt gggcgtcact ccccacccac1141 gctgcacacc ggccccaggg ccctgccgcc tgggcctcca cacccatccc tgcacgtggc1201 agctttgtct ctgttgagaa tggactctac gctcaggcag gggagaggcc tcctcacact1261 ggtcccggcc tcactctttt ccctgaccct cgggggccca gggccatgga aggaccctta1321 ggagttcgat gagagagacc atgaggccac tgggctttcc ccctcccagg cctcctgggt1381 gtcaccccct tactttaatt cttgggcctc caataagtgt cccataggtg tctggccagg1441 cccacctgct gcggatgtgg tctctgtgtg tgcgtgtgtg ggcacaggtg tgagtgtgtg1501 agtgacagtt accccatttc agtcatttcc tgctgcaact aagtcagcaa cacagtttct1561 ctgatgtcga aaaaaaaaaa aaaaaaa<210>11<211>1498<212>DNA<213>Homo sapiens<400>111 cagagtttgg gcgccaggcg agacggcagg gcttaaagtt ccgggaatca aagatcaact61 cccactgagg acaaatggac ctgtaattcc gggtgtgacg agagaacgag atttaccttc121 ctgaattaaa aaacaggtca ttaagcttgg gccctgactt ttctttgtga gaaggtacag181 agatggaaac cttacaatcc gagactaaaa cgagggtcct tccctcatgg ctgacagccc241 aggtggctac aaagaatgtg gcaccaatga aggcccccaa gaggatgaga atggcagcag301 tgccagtggc agcagcaaga ctccctgcga caaggactgt gtactgcatg aatgaggctg361 agatagttga tgttgctctg ggaatcctga ttgagagccg caaacaggaa aaggcctgcg421 agcagccggc cctggcgggg gctgataacc cagagcactc ccctccctgc tccgtgtcgc481 ctcacacaag ttctgggagc agcagtgagg aagaggacag tgggaaacag gcactggctc541 caggcctcag cccttcccag aggccggggg gttccagctc tgcctgtagc aggagccctg
601 aggaggagga ggaagaggat gtgctgaaat acgtccggga gatctttttc agctagggca661 taaactgtgc actgaactgt ctgccgagag cagctggagg acagctgagc ttccactggt721 gctgctgggc cgcccgcctg tgggaatggg gctctctgtg ctcctacctt tgtgccttct781 tgggcctggc agattcacct caggccagaa gcccctggac actccgggcc ttggggctgc841 cgttctgagt gtgcggaagg caggactcaa aatgagatcc catttgactc cctctgtatg901 tactgtgccc tctcctggct cttgaggctc tggagtccca attgtctgtg ttagtcagtg961 accaggttcc agggaaaatg atgtcatgtg gtggtccaac ttactggaac caaagagaca1021 gtactttgca aagaaaagga tcactgccag gtgcactgga attgctacag tttagtccgc1081 atgatctctc ctgaaggagg aagcctgttt caaaaatagt ttccatcatg agtctatcaa1141 tgagctccca cctctccagc cagcctagaa agcaaacgag ctgcccacag ttctctgccc1201 tgtctgggag gttgaggcca cagtgtatag actggtaagc cagacaggcc tcctcccgca1261 agctgctacc ttgctttcac ctgtaccttg gtccccgggc agctagctat aaagcaagag1321 ggacaggagc ccagaagaga cactgaggac aagagatcac accagagtac atgtctctgc1381 ctctgttttc agtgtggctt tggacaggaa tatatgaata aatcactgcc atacaggttt1441 tccaatacac aagtgctaga aaatacacac aattccccaa tgaaaaaaaa aaaaaaaa<210>12<211>1534<212>DNA<213>Homo sapiens<400>121 tcagtgggcg tcgcgcgaag gctaagggag tgtggcgggc ggctccggga gccaacatgc61 ctcggtatgc gcagctggtc atgggccccg cgggcagcgg gaagagcacc tactgtgcca121 ccatggtcca gcactgtgaa gccctcaacc ggtctgtcca agttgtaaac ctggatccag181 cagcagaaca cttcaactac tccgtgatgg ctgacatccg ggaactgatc gaggtggatg241 atgtaatgga ggatgattct ctgcgattcg gtcccaacgg aggattggta ttttgcatgg301 agtactttgc caataatttt gactggctgg agaactgtct tggccatgta gaggacgact361 atatcctttt tgattgtcca ggtcagattg agttgtacac tcacctgcct gtgatgaaac421 agctggtcca gcagctcgag cagtgggagt tccgagtctg tggagttttt cttgttgatt481 ctcagttcat ggtggagtca ttcaagttta tttctggcat cttggcagcc ctgagtgcca541 tgatctctct agaaattccg caagtcaaca tcatgacaaa aatggatctg ctgagtaaaa601 aagcaaaaaa ggaaattgag aaatttttag atccagacat gtattcttta ttagaagatt661 ctacaagtga cttaagaagc aaaaaattca agaaactgac taaagctata tgtggactga721 ttgatgacta cagcatggtt cgatttttac cttacgatca gtcagatgaa gaaagcatga781 acattgcatt gcagcatatt gattttgcca ttcaatatgg agaagaccta gaatttaaag841 aaccaaagga acgtgaagat gagtcttcct ctatgtttga cgaatatttt caagaatgcc901 aggatgaatg aagagtttac taaaagtaac catctaaaga gcttgtggcc aaaccagcag961 aacattcttc tcttcaaagg atgcaatagt agaaagctac ttattttaat gaaaaaaagt1021 aaaacttcgt tctttatcag cctcatgcct gaatcaaatt tttaattatt ctgaaactgc1081 tgctgtttaa agtggaatct tttagtatta taacagcatc actttagatt ttgtaagtca1141 aaattgaaat gaatgcacat agatttatat ataaattagc acctgagcta aggttaaggc1201 tggtctaaac ttattttcac tttttgtatt atttttgaga tgcaggaatt actgtaacaa
1261 aatatgtatg tccgaaggga aaaagctgca aggatatata taagaccact gcttatctgt1321 atcttcccat tttcctatat tgaaaatgta tattatttat ataacttaaa aagtaaaaat1381 aactatgttt tgagatatgt atgtgtatat ataaaagaaa caaaggtttt taatgattct1441 tggacctaga taacaagtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa<210>13<211>1624<212>DNA<213>Homo sapiens<400>131 gagggatgca ggccagccag ggatccagcg tcttccccat cgtcactctc catggcctcc61 gtctacacac agtgttcgtc tgcacagctt gtcagcgcgt tatcatgact tctatttggc121 accggcccgt ctgtccactg tcctggcttg ttccaagcgc tgccttctcc aactggggtc181 ctggctgcag agctgtctgc tccccacgtt gggcaactcc agccaagatt cctacaccca241 aatgtgaccg tgttgctcac gaagaaggct cagctttgcg tgtgcccagc cgtgtgcaca301 gctcgtccca actcctgcgg gtggcacctg cctctcccac ctccagtctt tcccctgtga361 tgagcagatg accaccgccc tccagggtca gcgtttggct gtttgtgtgc ctgcccaccc421 gcctccctgt gcctgggcct gccctgtgcc tgcacacagg agtggctcat ggcgtttgcc481 ctacacggat gggctgtcct gggagctact ggacagtcac cttggtggga atgccagagg541 catgggcatt aggtcccccc ggccagcctc cgttgccaca tgggctattt ttgtccatcg601 cgtgggacaa cctagtattg ggggaaaact cagtccactc taaagaagca tcggcgtttt661 ggatggacga atgctgcttc atgcgtctcc atgtcaatgg actattttat tcaactcggg721 tatttatgag tgtctcctct gtgccagcca cgtgtgaaag aagaactcca agttactgga781 caccaggaca aaccaggtag atcactgcat ccggttcctc ctctttctgc cgactctccc841 gggcaaccgt tctgattcct ggcatggagt tgggggcgag ctcatcagta cccagagcgc901 ctggtgtgca gccaaaggcc cccattttat tagtcggtgt gttcagtatc acgctcaaga961 caagggccaa cctattactt cacacacctc aaatacaaaa agtgcctggg aacgtcgatg1021 aggtattaaa ggaaaccact ggtcttgtca gtcatgtaca cacagaaaaa aaaaccagtc1081 atttttattt ttattttttg agacagagtt tcgctcttgt tgcccaggct ggagtgcaat1141 ggtgcaattt cagctcactg caatctctgc cacccggatt caagcaattc tcctgtctca1201 gcctcccgag tagctggaat tgcagacacc catcaccacg cccagctaat tttatgtatt1261 tttagtagag atggggtttc accatgttgg tcaggctggt cttgaactcc tgacctcagg1321 tgatccaccc acgtcaggct cccaaagtgc tgagattaca ggcatgaacc actgtgccca1381 gccgaaaaca accaagaatt ttttaacaat aaaatgacca gcaagtaaac ttgaaacaaa1441 aatggacaaa tatctaaaat atttttaaat gtatgtattt taattggcaa ataatacttg1501 tatatattgt ttacaacttg ttttaaagta tgaatacatt gtgaaaaaaa aaaaaaaaaa1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa1621 aaaa
<210>14<211>1962<212>DNA<213>Homo sapiens<400>141 gtggctcata agtgtctcta agttatacca aaagtttgag cacaacagta gtagcagaat61 gcttagaata aatgcttgac ttttaagctg acttttggaa ggaccatacc cacatagagg121 catcttttct gctgtggtaa ttttttaaat taatacattg ctttaggatt acatctcaaa181 gtaaataaaa aaatcaatat ttaatttgtt tttttcctgc aaataaatta aatgctggga241 ccataatgat tatttttgca tagtaatagc tggtgaagaa gttgttttaa aattaaattg301 ccaaaagtat tacctcttga aaaatttatt ttcccaaagt ttttcatatg tcatgaaacc361 cctaatcttg acctttatga cacagtggca ttacactgat gttggaagca tgtgtgagat421 ctgtgccctg gtcgggagtc atatgcctta aaaatgactg cgagtcagtg tgaagtagta481 taaagtggag tcctacgtgg gaaaaagcag gctactgagg acaaaaacct cccaaccctc541 cccaccttgt tttccactgg gaatgagaat ttgatatgag aaacttcaac cttgcagaag601 tgtggatttc cctctgaaat ttaaatgttt cacacatttt tgtacctttt gtaaccttgt661 ggtatttact ttcacatggc tttttaaaaa attattttaa tgaacttcta tcacactata721 tgaatgatat gggggaaata ctgaactgct catatttcct tttttggcaa taaagcactg781 ttatatgtaa atgtaagtga aaaagaggtt caagactata caacagctta tgtgtagtat841 atgttgacat ccctaaggta ttttgaaaca tgaggtgaca gacaaggacc tcaaatttcc901 agggaaatat ttatttcaca acattaggag tgtagctctt cataatgaaa tatcttcttt961 ctgctaaaga ttacaatttt tcatttaggg aactgtgaat attttctgtg aggtttacag1021 aaactagtgt atccttttca ctatgttgaa aagacaatct gaactttagc tatttatatt1081 tcagtattaa cacaccttca ctgattgaga gtcttgagcc cttctctact tttataaagt1141 gaatcctatt tccaagtcat ccatgtcttt tgaagtctgt ttcttatata agtatttatt1201 actttactgt ttagcataaa taggagacag aaaaggataa taaactacta ggtcctttat1261 tcctattaaa ataaatttat aaatcccttg aatcaactga attctaagct ttttgaagag1321 gttgctgatg tagtgtgatc aaaagaatct aaggagaacc tcatctccaa aatctgattg1381 gagctgttca ccctctcaag gacaagataa agattgactt cagagatata tcacatcaag1441 ctagaggaaa aaaaaaaaac ctcaaataaa atttttcctc attcgaaggg atccagggta1501 tccttgggtt atgtaggagg gaatcatatt tgttctaatt tacctgaatg tacttgtgtg1561 tgaatccaat cttgattcta aacaccaaat cttgtcaaca gtagagaagt atagtaagga1621 gttcctgttg tcaatcaaat gagggtgtga aacatttaga atgctctgtg ttacacttga1681 accatgtata aatgtaacct gtgtatcttt tttttaatta gcttttctga atttaaatta1741 tattgttttt ctttgtattg ttagcaaaat gcatcagaac tggatttttt ttctcatctg1801 aacataatat aaaatttgaa agagtattgt gatattaagc actttaacat acatatcaga1861 caaactgacg tgggtttttc aggtttggga gtacatttaa atatgacttt tcatgctttg1921 ttctttacaa ataaaactgt gggattgata aaaaaaaaaa aa<210>15<211>1849<212>DNA
<213>Homo sapiens<400>151 gcacagtatc tgggtccagc ctgcagccct agggtccagt tcagagtctg tcatctgaac61 catgaggatc tggtggcttc tgcttgccat tgaaatctgc acagggaaca taaactcaca121 ggacacctgc aggcaagggc accctggaat ccctgggaac cccggtcaca atggtctgcc181 tggaagagat ggacgagacg gagcgaaggg tgacaaaggc gatgcaggag aaccaggacg241 tcctggcagc ccggggaagg atgggacgag tggagagaag ggagaacgag gagcagatgg301 aaaagttgaa gcaaaaggca tcaaaggtga tcaaggctca agaggatccc caggaaaaca361 tggccccaag gggcttgcag ggcccatggg agagaaaggc ctccgaggag agactgggcc421 tcaggggcag aaggggaata agggtgacgt gggtcccact ggtcctgagg ggccaagggg481 caacattggg cctttgggcc caactggttt accgggcccc atgggcccta ttggaaagcc541 tggtcccaag ggagaagctg gacccacggg gccccagggt gagccaggag tccggggaat601 aagaggctgg aaaggagatc gaggagagaa agggaaaatc ggtgagactc tagtcttgcc661 aaaaagtgct ttcactgtgg ggctcacggt gctgagcaag tttccttctt cagatgtgcc721 cattaaattt gataagatcc tgtataacga attcaaccat tatgatacag cagcggggaa781 attcacgtgc cacattgctg gggtctatta cttcacctac cacatcactg ttttctccag841 gaatgttcag gtgtctttgg tcaaaaatgg agtaaaaata ctgcacacca aagatgctta901 catgagctct gaggaccagg cctctggcgg cattgtcctg cagctgaagc tcggggatga961 ggtgtggctg caggtgacag gaggagagag gttcaatggc ttgtttgctg atgaggacga1021 tgacacaact ttcacagggt tccttctgtt cagcagcccg tgacagagga gagtttaaaa1081 atccgccaca ccatccatca gaatcagctt gggatgaact tattcagatg gttttacttt1141 attaattcct ccaattatta caataatcat aaaaaggtga aaatggaaaa gttattccca1201 aaactgattc tgtgtaactt actatttttc caggagtaaa tatttaaaat agctgcatgg1261 tttattctaa tttatttcac atttcttatt cctattatct gaagaatccc tcgtctgtgc1321 gtttcttgtg ggaagagtgt tttaatatca ttttagtgct ctgaggagtc atatgaagat1381 gtatccctca tctgtgtttc tgaggacatt aaggggaaat tagagggaaa tgtttattca1441 atttagtact agcaacagct ttaagctggt gatgctgtca tactccagaa agctgtagac1501 actgctcatt ttgtctttta aaaaaatttt attttatttt aagttctggg atacatatgc1561 aaaacatgca tgtttgttac ataggtaaac atgtgctgtg gtggtttgct gtatctatca1621 acccatcacc taggtattaa gccctgcatg cattagctat ttgtcctggt gctctccctc1681 ccactttgct cattttctaa cctaggtttt aatcaccatt ttacccaaca aatcattgtt1741 cgatcattat ttgccagact tgaatctcta tgtgttttct aggactgctc taataaagta1801 cacaaactgg gagtctttaa acaacaaaaa aaaaaaaaaa aaaaaaaaa<210>16<211>1870<212>DNA<213>Homo sapiens<400>161 agtctagtgg gataccaggc cctgagagac ccctacgatc ccaggacact gatgtggggt61 aactaacacc cactggaagt ctacgctgag ttcacaggct atgtatgacc tgacatgcat
121 tttgacctgc cctgtgtttt gatatttgaa tgagttgctg atgtttacaa gccgaagctg181 gccgggcgtg gtggctcgcg cctgtaatcc cagcactttg ggaggtcgag gcaggaggat241 cgcttcaggt caggagttcc agaccagtct ggccaacatg gcgaaacctc gtctctacta301 aaaaaaaaaa aaaaaaaaat acaaaaatta gccgggcgtg gtggcacgcc cctgtaatcc361 caggactcgg gaggctgaga caattataaa ttcattaacc cccagaactc ttggctagac421 ttcataaagg caaaaactgt gtttgccctg ttaactgctt tatcccacca ctagaatata481 agcttcctga agacagaaga cttctgttat tttgttcaca gttaccaagc atgcctactt541 tgttaaattt atgaaagaac tttaaagagt cagaggttcc ggttgagatc aagttgggag601 acacaccctt gttcattctc cttgagaagc agctattatc aacagaacat tgacggaacc661 tgtgtttggg gaaaggactg atggctttga gtctaggttg gaaagcacac aggaaccact721 gtggtctcct cttgcaggct ctgcgaagca gtggtcttct cttgtttccc tgtggccagt781 gtccctggag aggagctgga agctttttgg accctgagat aaaggctttc ctggaggaga841 acactgaagt caccagcagt ggtagcctca cccctgaaat ccagttgcgg cttttgaccc901 ccagatgcaa attctggtgg gagagagctg acctgtggcc ccacagtgat ccttactggg961 caatctactg gccaggaggc caagccctgt ctaggtatct tttggataat cctgatgttg1021 tcagaggaaa atctgtatta gatcttggga gtggatgtgg agctacagct attgctgcta1081 agatgagtgg ggcatcaagg atcttggcca atgacataga ccctattgca ggaatggcta1141 ttacactaaa ttgtgaattg aacagactga atccttttcc tattttaatc caaaacattt1201 tgaatttgga acaagataag tgggaccttg ttgttcttgg cgatatgttt tatgatgaag1261 accttgcaga tagtcttcat cagtggctga agaagtgctt ctggacctat agaactcgag1321 tactgattgg tgaccctggg cggccccagt tcagtggaca cagcattcag catcacctgc1381 acaaagtggt agaatattca cttttggagt ctactaggca ggaaaacagt ggactgacaa1441 caagcacagt gtggggtttt cagccttgag ttgtcaaagt gcttccaagt atgaatatag1501 taatgtttgg atctgactct aaaagttttc tctataggag atactctcca gtttaatgaa1561 tgtaattctt gttaaatgga aaatcttgtt tttaaaatat gaaggtttag agttttgttt1621 acttttgtca tgtaactggt tctgtatttc tatgcatgcc aattatacac atctctatct1681 gcattttttt ttctatttta accgctgaag gaatatgatt atacaatgcc atactcaatg1741 gtggcagcat ttaatttaag taatggagaa gaattaaaca ttgtagctgg atctgtttct1801 gtagtcgagg acaactgtga tgtaactttg aattaaacaa acaaaacaaa acagaaaaaa1861 aaaaaaaaaa<210>17<211>2145<212>DNA<213>Homo sapiens<400>171 caggccaccg cggcctgtga cgcgcacctc ggcgcccaag gcccgtagcc gcgcagtttc61 ctcgggcgtc aggccgccgc gcagcccggc cgtatacacg ggccccacgg gctcgcagag121 caggagcgcg cccgcctcag tccccgacgg ggcctcaatg cctggctcgg cctgcagccg181 ccgcagccag cggtcctgca gccccagtag ctcggcgtac ggcacccgac ccaggcgcac241 cagccgaacg gcgggttgcc gcatcgtgcc caccgttgcg tccgcggggc cccgccctct301 ccgtgggcct gggggcgtgg cctgaggggc ggggactcgg gggcacaccc cgagccgcag
361 ctcccaggtg cgtgttaaaa gctggagggg ggatatgtga tcccaggacc aaaagcgcgg421 ggccagactc atcggttcat tcaacaacca gtatttagtg cctgctgtgt tctgcaggcc481 ctgccatagg cgcttgatac agcggtgcat agcgtatgag aaagatctgt cctggctgag541 catccgtaat ataaaaatct gaaatctgaa atgctccaaa atcctaaact ttttgagtgc601 tgacattatg ccacaaatgg aaaatttcat acctgacctt atgtgagttg cagtcaaaac661 acaggtgcac aacacccagt tcatgcaaca tccccaatgg gaaaaaagac ccccccagct721 ctcttctgct gcagtttttc tgctcacacc tggatttccc catgcattcc cacaaaaagt781 aattaaatgg catgcgtgca ggctggacac gccaacaaca ggtttcccac aatgccccac841 atggggccaa gacctgtgtg cattactcac tgcatttttt tgcttattct ctgctgtgtg901 gtataaatat attgttgaaa atgtcaaaaa gacctaaaga tacccctgtg aatatcagtg961 ataagaaaaa gaggaagcat ttatgtttat ctatagcaca gaaagtcaag ttgttggaga1021 aactggacag tggtgtaagt gtgaaacatc ttacggaaga gtatggtgtt ggaatgacca1081 ccatatatga cctgaagaaa cagaaggata aactgttgaa gttttatgct gaaagtgatg1141 agcagatatt aatgaaaaat agaaaaacac ttcataaagc taaaaatgaa gatcttgatc1201 gtgtattgaa agagtggatc cgtcagcgtc gcagtgaaca catgccactt aatggtatgc1261 tgatcatgaa acaagcaaag atatatcaca atgaactaaa aattgagggg aactgtgaat1321 attcaacagg ctggttgcag aaatttaaga aaagacatgg cattaaattt ttaaagactt1381 gtggcaataa agcatctgct ggtcatgaag caacagagaa gtttactggc aagttcagta1441 atgatgatga acaagatggt aactttgaag gattcagtat gtcaagtgag aaaaaaataa1501 tgtctgacct ccttacatat acaaaaaata tacatccaga gactgtcagt aagctggaag1561 aagaggatat caaagatgtt tttaacagta ataatgaggc tccagttgtt cattcattgt1621 ccaatggtga agtaacaaaa atggttctga atcaagatga tcatgatgat aatgataatg1681 aagatgatgt taacactgca gaaaaagtgc ctatagacga catggtaaaa atgtgtgatg1741 ggcttattaa aggactagag cagcatgcat tcataacaga gcaagaaatc atgtcagttt1801 ataaaatcaa agagagactt ctaagacaaa aagcatcatt aatgaggcag atgactctga1861 aagaaacatt taaaaaagcc atccagagga atgcttcttc ctctctacag gacccacttc1921 ttggtccctc aactgcttct gatgcttctt ctcacctaaa aataaaataa aatacagtgt1981 acagtaacct tttagtcaaa acagcatcat acttggaaac tgaaagccta ctgttatttg2041 ttattgttgc ttaacagctg atacagatat tctggtgaca ctactgtgct ggcttactta2101 acctgaatac actatttttt tcgttgtaaa aaaaaaaaaa aaaaa<210>18<211>1501<212>DNA<213>Homo sapiens<400>181 ctgggggggt ttgttgggct ggtgagtttt cgaggtgact gtgctgtgct cggtgagggg61 acgcccagag agccctgacc cggggtcact ccgtcgccgt tctcctcttg tctacgtgct121 ggacccggtg ctaccttttt acccacactt aagtgacgca aaatgccctt caatggcgag181 aagcagtgtg tgggagagga ccagccaagc gattctgatt cttcccggtt ttccgaaagc241 atggcttcgc tcagtgacta tgaatgctcc aggcagagct ttacaagtga ctcctccagc301 aaatccagct ctcctgcttc aacaagccct ccaagggttg taacatttga tgaagtgatg
361 gctacagcaa ggaacttatc aaacttgact cttgctcatg agattgctgt aaatgagaac421 tttcaattga aacaagaggc tctcccagaa aagagtttgg ctggttgagt gaagcacatt481 gttcaccagg ccttctggga cgtcttggat tcagaactaa atgctgaccc tcctgagttt541 gaacatgcca tcaaactgtt tgaagaaatc agagagattc ttctctcttt tctcactccc601 ggtggcaacc ggcttcgcaa ccaaatctgt gaagttttgg acacagacct cattaggcag661 caggctgagc acagtgctgt tgacatccaa ggcctggcca actatgtcat cagtacgatg721 ggaaagctgt gtgctcccgt gcgagataat gatatcagag agttaaaggc tactggcaac781 atcgtggagg tgctgagaca aatattccat gtcctggacc tcatgcaaat ggacatggcc841 aattttacaa ttatgagtct cagaccgcac cttcaacgcc agttggtgga atatgagaga901 accaagttcc aggaaatttt ggaagaaact ccaagaaaag ccgaggttgc aggtgcctca961 tgaggctgac cttgcttttg gaaccagaga gagcagtcac cgtgccagcc tgtgagagtg1021 aagtctctgc cgatccctaa gagaagagcc aacgtttcac tctaaacgca tgctccttct1081 gctttaccgg tcattctcaa gtctgactac aaattagaat catctggggc gtttaaacac1141 agaggcctga gccctgcctc agacagaata aatcaaagtc tccaggagct gtgcccatga1201 actctttttt tcctttttaa agctccccag gtgattctaa agtcagccag gattgagaac1261 cactatgcca cactgttgct tttgttcaag gtaactaaat gggctcttaa atgtgtcagc1321 tgtaaatgat taaacttgca gtataaatgc ttattactgc cacattgtaa ttatattcac1381 gatgatttcc actcgcgctc tctcagttgg atgtctttta aatgaaagac tgcaagtctt1441 ttacatcttt ataaaacaga actagcaaac caaaaaaaaa aaaaaaaaaa aaaaaaaaaa1501 a<210>19<211>1434<212>DNA<213>Homo sapiens<400>191 acgcacgcaa gcggctccag ggtacgtccc cgccacgcgc gctcgcagga tcggtgcgtg61 gtgacgtttc gccggcgcgg gcgccatccc ggaagcgcga gcaaggccgc cagatgtgca121 ggcagcggag gaggagaaag agatggacct cccggactcg gcctcgaggg tcttctgcgg181 ccgcatcctg agcatggtga acacagatga tgtcaacgcc atcatcctgg cccagaagaa241 catgctggac cgctttgaga agaccaatga gatgctgctc aacttcaaca acctgtccag301 tgcccgcctg cagcagatga gcgaacgctt cctgcaccac acgaggaccc tagtagagat361 gaaacgggac ctggacagca tcttccgccg tatcaggacg ctgaaaggga aactggccag421 gcagcaccca gaggccttca gccatatccc agaggcatcc ttcctggagg aagaggatga481 agaccccatc ccacccagca ccacgaccac cattgccacc tcagaacaga gcacgggctc541 atgtgacacc agccccgaca ccgtctcgcc ctccctgagc cccggcttcg aggacctgtc601 ccatgtccag gctggctccc cagccatcaa cggccgcagc cagacagatg acgaggagat661 gacgggcgaa tagccctgct gcccggtgcc ttgagggggt ctcagggcag cagcatacaa721 ggtggcagcg ggtaaccctg ccttgttctg tcatccaggg ctcctttgct gccccgttct781 gtcacccagg gctcctaggg ggacaaggct ctctcccgag gggtgtggaa ttcctggggg841 ggtctttaat tctggctcct tccttcctca gaacatctct attctgcaag acccctctgc901 catgccaggg cacgcccatt ccagctggag tcgtggggct gggcacaggg gaatttttcc
961 agagctgagc ctgacgtctg ctctgaagaa tgcttagaag gttcccagac accagagcca1021 gatgtccccc accaccggtc aggacctcct tgaggtgcac aagcacggtc tcctctgagt1081 tcaccccagc ccacccccgc acccactaat tctgcttttc ctgccccttg ctccgtaaaa1141 gtatcaaata ctttctcctt ggtatctcaa ggaggtttct gagataggta gaagtcttga1201 gacggaggct ggccatccat tcagccctga gcgtgctgag ttctgtgttt ctctgaatag1261 aggtgtggaa cctgaggggc cagcaggcct ctctgaaggc ctccatggag caaacggagc1321 cacctcggga aagagtttaa tggaatattt ttgtacccga tgtttacaga tgctgttggg1381 aagttatcaa taaaaagaca ccattactaa aaagggaaaa aaaaaaaaaa aaaa<210>20<211>1226<212>DNA<213>Homo sapiens<400>201 gtcatcgccg cggggcggag gcgacagtgt ctagcgggag ctccgcgtgt agctacgccg61 gccgcctggc tttgagacaa cgtgattctc cgcagctggt cgcctacccg tgatgttctg121 cccacgtcga gacctgagct gaaatggcag acgatctcgg agacgagtgg tgggagaacc181 agccgactgg agcaggcagc agcccagaag catcagatgg tgaaggagaa ggagacacag241 aagtgatgca gcaggagaca gttccagttc ctgtaccttc agagaaaacc aaacagccta301 aagaatgttt tttgatacaa ccaaaggaaa gaaaagagaa taccaccaag accaggaaaa361 gaagaaagaa gaaaattact gatgttcttg caaaatcaga accaaaacca gggttacctg421 aagacctaca gaagctgatg aaggactatt atagcagcag acgcttggtg attgaattag481 aagaactgaa cctgccagac tcctgtttcc tcaaggccaa tgatttgact cacagtcttt541 cctcatacct aaaaggaatt tgtcctaagt gggtaaaact taggaagaac cacagtgaga601 agaaatcggt cctgatgctg atcatctgca gctcggccgt ccgagccctg gagctcatta661 ggtcgatgac agcattcaga ggagacggca aagttataaa attatttgca aagcacataa721 aggtccaggc gcaggtaaag ttgctggaga agcgtgtggt gcacctgggt gtaggaactc781 cggggagaat taaagaactt gttaaacaag gtggccttaa tttgagcccc ttaaaatttc841 tggtttttga ctggaactgg agagatcaga agttgaggag aatgatggac attcccgaga901 taagaaagga ggtattcgaa cttctggaaa tgggagtgct cagtctgtgc aagtcagaat961 ccttgaaact gggccttttc taagtctgtg tcctaatgaa gattccagtt ttcacagtag1021 aagttgcatc ttatttaatg actctgatac attgcaagca ctcagtaaat atcagcaaat1081 agtttatgtt aattgtgtca acagatggat cactggaatg tggggattct gaaacagaaa1141 tgaaactgtc cttttgacaa ctctcttata taataaagta tcaccggctt gtgtatgaaa1201 aaaaaaaaaa aaaaaaaaaa aaaaaa<210>21<211>2216<212>DNA<213>Homo sapiens
<400>211 cgtctctctg cccccgccgc tgccatggcg gcagctccgc cgctttccaa ggccgagtat61 ctgaagcgtt acttgtccgg ggcagatgcc ggcgtcgacc ggggatctga gtccggtcgc121 aagcgtcgca aaaagcggcc gaagcctggc ggggccggcg gcaagggaat gcggattgtg181 gatgatgatg tgagctggac agctatctcc acaaccaaac tagaaaagga ggaagaggaa241 gatgatggag atttgcctgt ggtggcagag tttgtggatg agcggccaga agaggtaaag301 cagatggagg cctttcgttc cagtgccaaa tggaagcttc tgggaggcca caacgaagac361 ctaccctcaa acagacattt tcgtcacgat accccggatt catctcctag gagggtccgt421 catggtaccc cagatccatc tcctaggaag gaccgtcatg acaccccgga tccatctcct481 aggagggccc gtcatgacac cccagatcct tctcccctca gaggggctcg tcatgactca541 gacacatctc ctcccaggag gatccgtcat gactcctcag acacttcacc cccaaggagg601 gcccgtcatg attctccaga tccttctccc ccaaggaggc ctcagcataa ttcttcaggt661 gcatctccta ggagagtccg tcatgattca ccagatccct ctcctcctag gcgagcccgt721 catggttcct cagatatctc ttcccccaga agggtccata acaactcccc tgacacatct781 aggaggactc ttggctcttc agacacacag caactcagaa gggcccgtca tgactcccct841 gatttggctc ctaatgtcac ttattccctg cccagaacca aaagtggtaa agccccagaa901 agagcctcta gcaagacttc tccacattgg aaggagtcag gagcctccca tttgtcattc961 ccaaagaaca gcaaatatga gtatgaccct gacatctctc ctccacgaaa aaagcaagca1021 aaatcccatt ttggagacaa gaagcagctt gattccaaag gtgactgcca gaaagcaact1081 gattcagacc tttcttctcc acggcataaa caaagtccag ggcaccagga ttctgattca1141 gatctgtcac ctccacggaa tagacctaga caccggagct ctgattctga cctctctcca1201 ccaaggagga gacagaggac caaatcttct gattctgacc tgtccccgcc tcgaaggagt1261 cagcctcctg gaaagaaggc tgcacacatg tattctgggg ctaaaactgg gttggtgtta1321 actgacatac agcgagaaca gcaggagctc aaggaacagg atcaagaaac catggcattt1381 gaagctgaat ttcaatatgc tgaaaccgta tttcgagata agtctggtcg taagaggaat1441 ttgaaactcg aacgtttaga gcaaaggagg aaagcagaaa aggactcaga gagagatgag1501 ctgtatgccc agtggggaaa agggcttgcc cagagccggc aacagcaaca aaatgtggag1561 gatgcaatga aagagatgca aaagcctctg gcccgctata ttgatgacga agatctggat1621 aggatgctaa gagaacagga aagagagggg gaccctatgg ccaacttcat caagaagaat1681 aaggccaagg agaacaagaa taaaaaagtg agacctcgct acagtggtcc agcacctcct1741 cccaacagat ttaatatctg gcctggatat cgctgggacg gagtggacag atccaatgga1801 tttgaacaga agcgctttgc caggcttgcc agcaagaagg cagtggagga acttgcctac1861 aaatggagtg ttgaggatat gtaactttcc tgaggctgtg ggggtggctg ggctgtggta1921 gtgggcatag gcagcgagat atccagtggt aacagttgtc tgtgctaata attggagccc1981 acacagacca gcaacttgtt gaatgccagt tttgaccaca gaagaatatt cgagacctga2041 tgtttggact gaggtacctg tacttcttgg gtgtgacagc accggctgtt gctggctttc2101 agaggaagca ttgatttctc attgaccagg gtttgttctt ggtagggttt ttctttttct2161 tttttaaata aacatgtatt tattttttta aaaaaaaaaa aaaaaaaaaa aaaaaa<210>22<211>2034<212>DNA
<213>Homo sapiens<400>221 gacgactcca cgctcgcttg ccctgattct ctccgccctg cacttttgcc agctgaaggt61 ccagggagaa gagcaacctg gcccacagcc tgcaggtggc ccagcagcag gccgaggagc121 tgccgcagga gcgggagaag ctgcaggttg cccaggagga gctgcagcgc cagcgggacc181 ggctggagga agagcaggaa gaggcggtgc agaatggcgc acgggttcgc cgggagcttg241 agcgcagcca tagacaacta gagcagctgg aagggaagcg ctcagtcctg gccaaggagc301 tggtggaggt gagggaggcg ctgagccgcg ccacgctgca acgggacatg ctgcaggccg361 agaagaccga ggtggccgag gcgctgacca aggctgaggc tggccgcatg gagctcgagc421 tctccgtgac caagttgagg gcagaggagg cctccctgca ggactccctg tccaagctga481 gcgccctcaa tgagagcctt gctcaggaca agttggatct gaactgcctt gtcacccagc541 tggaggaaga aaaggccacg ctgcagggcc ggcagcggca ggcggagcag gaggccacag601 tggcgccggc agagcaggag tggctggagg agctgtggtt ggagcaggag gtggcacggc661 agggcctgga gggctcccta tgagtggcgg agcaggccca ggaggcgctg gagcaacagc721 tccccacact gcaccatgag ctcagttggc tgcaggagca gctagcacag gggatcatgt781 tcggaccccc aggccagccc actgctgctc cttggcactt tcacggccct ggcgtgtccc841 cgtcatagtc cttatcagtc ccttgtattt acctggtcac cctccatctc tgagggtatg901 ggggccagat ggctcttgct gccctgatgt tttggggggt ctgcctgggc ccctcctggt961 gtgtcacacg cgtccagtcc tggcccccta ggaggcagca tggcgggagc tggaggccga1021 gcgggcccag ctgcagagtc agctgcagcg tgagcaggag gagctgctgg cccggcggaa1081 ggctgagaag gaacagctga gtgaggagat tgctgccctg cagcaggagc atgacgaggg1141 cctcctcctg gccgagagcg agaagcagca ggccttgtct ctgaaggagt ctgagaagat1201 ggcgctgtca gagaagttga tgggtacacg gcacagcctg gccaccatct ccctggagat1261 ggagcggcag aaaccagatg cccagagccg gcaggagcag gaccgggtag gcctgccgtc1321 gtagggaggc ttgcggagca ggagcgccct ctttccaccg agctatcccg cggtttccag1381 catcccatct ggcggactcc tcttcctctc tcttctccta ctctgggtct tctatcctgg1441 tgttccttga atgcctatct tccttttgtg cctcggaacc tctcacgcct gccacaagtt1501 actcttttcc ttggtagttc tgaactttaa ataaggtaat gcctgtaaga atgccataaa1561 tgctcaataa ttgtcatctg ttattatttt catcagtaac atcatctgaa tcatcagtat1621 tgtctgcttt taacagctgc atttttcatt gtccaaatat agtcacatac atttgaccat1681 tttataatta ttgaataata aattcgttct gctattttac aatgaaaaat aatgctgcag1741 agagcatttt tgcacatgta tcgtggcaga tgtaggccag aggctcttct ttatccatcc1801 tatggccaac ctatgaatgt atacacgttt aatgagattt tgccagcaat caaagccttc1861 agggaaaatg tccctagctc tttactacat cagatcaagg actctggata attggcataa1921 catcctggaa tagctgaaac agagatatta ttctctgctg tcctctgttg tctttgtctt1981 ttcacgtctt aataaaagtg ctggtgacaa gagtgtaaaa aaaaaaaaaa aaaa<210>23<211>1514<212>DNA<213>Homo sapiens
<400>231 cttgcatcaa caatacttca gtcatgatgt ttaaaaaggg gagctttgaa attggaggaa61 ccatacatcc agttgcaatt aagtataacc ctcagttcgg tgatgcattt tggaacagta121 gtaaatacaa catggtgagc tacccttcga atgatgacca gctgggccat cgtctgtgac181 gtgtggtaca tgccccccat gaccagagag gaaggagaag atgcagtcca gtttgctaac241 agggttaagt ctgctattgc tatacaagga ggcctgactg aacttccctg ggatggagga301 ctaaagagag caaaggtgaa ggacatcttt aaggaagagc agcagaaaaa ttacagcaag361 atgattgtgg gcaatggatc tctcagctaa gaggacggat gacagccttt agatctagaa421 ctagccctta gaaatggaat ggcttttttg ttttgttttg ttttattgtt ttgtttttat481 tattgttaat cttttctaca gaatgattgt ctctacctct ttatgccaga ggcagaacct541 acaggtgccc tttttggctt ttgttgttgt tgtaacatta gccccatgga ttgtaaggtg601 gtttactgag ttaaaacaga ttctgctttt gtaaaatgat ggcatcactg tggactgaat661 gaaatatttg tatagaaaaa agtgcttgaa aagtgtgttt ggaactcatc gatagggtaa721 ttctccaaaa atgcccaaac tctctttctg taattagcct tgccactttc ttcagtcact781 taaatggtga gattacacat cagtgcaaga tgaccattat ggttatggtc tactgcaagg841 ttgaaaggaa aaatggagga ttgtatttag gaaaagggac aactttgtgg ccacctgctc901 tgaaagtcaa aaggaaatgt aaattagtgt cattagtgtg ttggaagaga aatactattc961 agtaagcttc gccaaagaaa agtgagtcaa agttaatgtg tgtgtgcatt tatatgtagg1021 cagctcgtag accacatttt agccagcaac tggtaacaaa gagcttagtt ttccttgttt1081 gaatgctgta gatctgtacc tagtacccct cccatctact gatttgtttg tttttgtaac1141 caaacacatt ttcagataga aggagcctta aaaaaaaaaa aatcacattg agtaacttca1201 gtatgaatga atgagagtgt gtggagctac ccctcaccct ccaccccttt gtgcttttta1261 ttcccgaatt ttcccagtct cttaaacaga aaaatgactg atataattat cttttggaaa1321 ctgagcctta atttttttta gagggggaaa taagttttcc ccaactcaca cagcataagc1381 aatgtttgac agcaatataa tgccgttgta aactactgag agtattgtat ctgttctggt1441 aaccatgtac agaatgtgaa actgtcttat gaatataaat aaattctata tttctaaaaa1501 aaaaaaaaaa aaaa<210>24<211>1010<212>DNA<213>Homo sapiens<400>241 acttccggtc ggcgtgagcg tgaggtgtgg gtgttcgttt ctcaggtaaa acatggctaa61 aagcttacgg agtaagtgga aaagaaagat gcgtgctgaa aagagaaaaa agaatgcccc121 aaaggaggcc agcaggctta aaagtattct caaactagac ggtgatgttt taatgaaaga181 tgttcaagag atagcaactg tggtggtacc caaacccaaa cattgccaag agaaaatgca241 atgtgaggta aaagatgaaa aagatgacat gaaaatggag actgatatta agagaaacaa301 aaagactctt ctagaccagc atggacagta cccaatatgg atgaaccaaa ggcaaagaaa361 aaggctgaag gcaaagcgag agaaaagaaa ggggaaaagc aaagcaaaag cagtgaaagt
421 ggcaaagggt ttggcctggt agactcttaa aaccttggaa aatgccacat gggatagatg481 acggattaga atgtatacac atgtatactt tgatttcaac tgccaccaaa tgaaaaccat541 ttgttttcct attttaactt ggcctttttt cttcaattca aacccagcat aactcctcaa601 gtttgttttg ggaacttgaa taaaatattt tctttgatac atccaagctc tactgatact661 ttaactggat gctacccaat atccagttat aatcaggcct caacgttctg tcaggtatta721 atatggttag aattgttctt acaactggta attatagtca atagagataa aacagatgat781 gtactgacaa atttttgtga acttagattt taaagaaagt tgttgtataa tcatatcatt841 taaaaatact acattagggc tgggcatggt ggctcacacc tgtaatccca gcactttggg901 aggccgaggc aggtggatca cgaggtcagt tcgagactag cctggctaat acagtgaaac961 cccatctcta ctaaaaatac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa<210>25<211>1482<212>DNA<213>Homo sapiens<400>251 gaggcgccgg cggccacgcc gcggaaggcg cgggccgagc agagccgggc gttggagccc61 gcgcgcgcat ggaggcgttg ccggcagccc cctgagggca gcggggagac aagacccggc121 gacctcgcgc atccctcgag ccgccacgcg ctctcgccac cgggcggcga cgggccgcgg181 agccggcgcg gccatggcga cgggcggcca gcagaaggag aacacgctgc ttcacctctt241 cgccggcggg tgtggaggca cagttggtgc tattttcact tgtccactag aagtcattaa301 gacacggttg cagtcttcaa gattagctct ccggacagtc tactatcctc aggttcatct361 ggggaccatt agtggagctg gaatggtgag accaacatcc gtgacacctg gactctttca421 ggttctgaag tcgatcttgg agaaagaggg accaaagtca ctttttagag gcttgggtcc481 aaatttggtt ggagttgcac catcaagggc tgtatacttt gcatgttact ccaaagccaa541 agagcaattt aatggcattt tcgtgcctaa cagcaatatt gtgcatattt tctcagctgg601 ctctgcagct tttatcacaa attccttaat gaatcctata tggatggtta aaacccgaat661 gcagctagaa cagaaagtga ggggctctaa gcagatgaat acactccagt gtgctcgtta721 cgtttaccag accgaaggca ttcgtggctt ctatagagga ttaactgcct cgtatgctgg781 aatttccgaa actataatct gctttgctat ttatgaaagt ttaaagaagt atctgaaaga841 agctccatta gcctcttctg caaatgggac tgagaaaaat tccacaagtt tttttggact901 tatggcagct gctgctcttt ctaagggctg tgcctcctgc attgcttatc cacacgaagt961 cataaggacg aggctccggg aagagggcac caagtacaag tcttttgtcc agacggcgcg1021 cctggtgttc cgggaagaag gctaccttgc cttttataga ggactgtttg cccagcttat1081 ccggcagatc ccaaatactg ccattgtgtt gtctacttat gagttaattg tgtacctgtt1141 agaagaccgt actcagtaac aggccggaaa attgtgctct agaagaataa aactgaaaaa1201 ctctagagaa ttttttttcc ccattgatgt ttagaaagtt tgagactgaa acaggaaagg1261 ccataaaata tctggttcat atcacctgtt ggacatttcc ttttggattc atgctttctg1321 gaaggtttaa attcattaac gttaatagtt aattataact tttttttaac ttaagaggat1381 tcagggttaa gcaccaacta aattaaatca tgctatttaa tttaagtata aaaaaaaaaa1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa cc
<210>26<211>1385<212>DNA<213>Homo sapiens<400>261 gcggacgatg ccaagtccag cagagcttgc gctcggggct agaagagaga ctgagtctcc61 cttctcagtt tcattaggta atgggcgaca tggctccgtc tccacagcgg ggctttgctg121 agcttagcac gcagtctccc ggcggggagg aggcgcgcag tgccgggcgc cactccgtct181 ccagtacgcg ttaggcccgc gttcccaggt gcccgtctgg ccgctggact gttggccttt241 ccggagcgag ttttacttta ggaagaagcc cgggatcccg gtagtttagc ctgaagaaac301 gtggggcaga tgctgggcag ggcggggata ccgcgccaac acccgctgcc cagcggtcgc361 cctcctatgc agcggcgaag ggacgcccgc tgtgtctccg ccctgccccc aggcgcccca421 gtggctggag gtggcattct ccactggacg ggcgcgcctc aatccggggg acttccacag481 tgctgttccc gaggactacg cgtctcaact ctttgtcggg ttccctccct cccactgcca541 gtctgtcttc accgccgcgc agacctgggg ccgcccttca cagaggaagg gctccttgac601 ctcagccacc gtgaccccct cctttgtgtc acattctcag agagttggag ggattatgcg661 tcatcgtaaa cagggggaca gagcgccttc cacctgcggc gcatccatta agttccagtt721 accctcgaga ggattgtttt ttccacgaaa cccagatgca atgagagcct ggcttgtacc781 atctctaagc atcgaggctt ccccctcgtc tgggtggtgg ccttcgggca gtggctccgg841 aaaggccatc aaggcttccc cgtcgtctgg atggtggcct tcgggcagtg gactgtgtcc901 atagctgaaa accagacttg acagttctgg attcaggctg ttgtgggagc gggaaggtca961 aacacccaga aggaactgat gaatgtgaat ttccctctaa gaactgcttt gcctggccgg1021 gcgcggtggc tcacgcttgt aattccagca ctttgggagg ctgaggtggg tggatgccga1081 ggtgagtgga tcacgaggtc aggagttcga gaccagcctg accaacatag tgaaaccccc1141 gtctctacta aaaatacaaa aattagccgg gcctggtggc gtgcgcctgt aatcccagct1201 actcgggagg ctgagacagg agaatcgctt gaatccggga ggcagaggtt gcaggagctg1261 agatcacgcc attgcactcc agcctgggca acagagtgag actccatctc aaaaaaaaaa1321 acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa1381 aaaaa<210>27<211>1503<212>DNA<213>Homo sapiens<400>271 cggcccccgg gagctgtgct ctatggagct attgcggccg tgggtggtcg cgggcgatgc61 ggggctgcca gctcctcggg cttcgtagct cttggcccgg ggacctacta agtgctcggc121 tcttgtccca agagaagcgg gcagcggaaa cgcactttgg gtttgagact gtgtcggaag181 aggagaaggg gggcaaagtc tatcaggtgt ttgaaagtgt ggctaagaag tatgatgtga
241 tgaatgatat gatgagtctt ggtatccatc gtgtttggaa ggatttgctg ctctggaaga301 tgcacccgct tcctgggacc cagctgcttg atgttgctgg aggcacaggt gacattgcat361 tccggttcct taattatgtt cagtcccagc atcagagaaa acagaagagg cagttaaggg421 cccaacaaaa tttatcctgg gaagaaatta ccaaagagta ccagaatgaa gaagattcct481 tgggcgggtc tcgtgtcgtg gtgtgtgaca tcaacaagga gatgctaaag gttggaaagc541 agaaagcctt ggctcaagga tacagagctg gacttgcatg ggtattagga gatgctgaag601 aactgccctt tgatgatgac aagtttgata tttacaccat tgcctttggg atccggaatg661 tcacacacat tgatcaggca ctccaggaag ctcatcgggt gctgaaacca ggaggacggt721 ttctctgtct ggaatttagc caagtgaaca atcccctcat atccaggctt tatgatctat781 atagcttcca ggtcatccct gtcctgggag aggtcatcgc tggagactgg aagtcctatc841 agtaccttgt agagagtatc cgaaggtctc cgtctcagga agagttcaag gacatgatag901 aagatgcagg ctttcacaag gtgacttacg aaagtctaac atcaggcatt gtggccattc961 attctggctt caaactttaa ttcctttcct atcatggagc atgaaccagt catatcctgt1021 tgaaagcctg gaactgaagg ataatctggc aaatgagaca gcagcagagc atctcctctt1081 aaggatacgt gccttggact catgtttgaa tcgaacagtc tcaaagtgga agaacaaatt1141 cttgtcactt ttttacagct ttctttggag ctgcttcagt ccatctccca gaggcatttg1201 gtctgtatct ttgctcaact gctaatttct cttggctgta gggtgtgtgg ttaaggtaca1261 accaccccta aagctcagtt ttgaagtgag tgtatttata gcttctctgc tggtgctgcc1321 ttctagaggg atgatagatc atttgaaccc aatgacaatt tttaaccaga aaatttaatt1381 gtacctgaat caacctttca gcctaggacg aagtctaggc ccaagtcaga gtattaatga1441 tcatgagaat tgtgtgctga accagtaaac gagtttacct tttgaaaaaa aaaaaaaaaa1501 aaa<210>28<211>457<212>DNA<213>Homo sapiens<400>281 gtgaggtctg gggatgagga cagtgtgtcc tgaaattcac aggactgact cctcacccca61 gtgcacgagg attcctgtgg catcaggtgc tgctgtacct ggtgtaggag cctaatcatg121 aaccattgtg ttactcacat tccatgtcac agaacatatc agcctcaaga aggatttggt181 ggaggtggat ttaccactgg ttttacaaag gaccgtgtaa agtcattgaa gttgtgaaag241 tctatttttt ttcctgtaaa tctatttttt acagaatata agaaacatca atgacctgat301 ctgtccttcc tcctccttcc cgcttccccc aaaatcacat tccagttttt attgtctttg361 tgtccaaagt aaactaggtg acttatttgt ataaaatgtt attttgccac atgagacagt421 aataaaagaa agattttcac agtaaaaaaa aaaaaaa<210>29<211>1685
<212>DNA<213>Homo sapiens<400>291 gtcaaaggaa gttagtacat taaacaaatg gtggtaggag ggaggatttg gcccaactgg61 ctccaaccta tctggtcaac acgtatgttg ggtagaacag aggtggagaa aagcctagat121 cagggatgta tacgcttcct tggggcagac gcagcctggc cctgcggagc gatttcaagc181 ctcgttcacg aacatggcca aggacactgc cagcctcttc attcccctgt gtggatgctc241 caactccaaa agtggaacca cagggcaaat gaatgtcggc acgtgtcggt atggcagcct301 cgctcttcga cagctggtgt gggggttacc acctggggct agctggcctc atcttcgtta361 gcactgagac tggtctacca gttgcacaga ttcagatttg aaaatctcag gtgcaaatcc421 caagtggcga tggcatgtaa ccacatcaaa ctcaacatct gcacctaact cccaccttct481 ttctctggga aatcttcctg gacatgccca gatggactca ggagcccatc acctgtaaat541 ccccacactg cagccctgcc acttgcttgt ctgcatgtgt gggtccgctg gaccactttg601 gtgtatcttt gagccccttg agtgaaaaaa tgctgcctgg ctggctccct gattagacat661 ccaacataat gaggactaac accaatacaa acacttaaga gatgacatat cgccctagct721 ggatctacta cagggaaggg aagagggtgc tgggtccagg caggctgagt gtctcatgtc781 ttaatgcttc tctgcccaat ctatttccgg ctggatgtgg agtctgaagg cctggcaccc841 actctggctc tgtgatttac cagctgtgag ccttggggga gctgcttact ctcttggtga901 ttcttttctc atttctatga tggggtagag gataatgcct atgcttacaa agtggctgtg961 ggaagtaaac cggatgggat aagaatggct tgctgtggac cacaggcacc gcaggataac1021 cattcctcag aactcctcgt actgctctag tgcttggagg tccgtgtatt acctcagcta1081 ttccaaccgc accaaccacg ggagccacgt gtctacgtct gacagataaa gatgctgagt1141 ttagagtctg caaggcttga caaccacaga tcagggacag gagctgaggt ctcctgacct1201 ggagcccagg gccacccgga gctgcaagaa acctgcactc acaactgcct cctattttaa1261 aatgctgagt cgatcccaca ggtggcaaac cagttctggg cttcaattta caagcagtca1321 gaaaagctgg gttgaaatcg ccactgtcct tctatgtggc tgatgaggaa ggatgacggt1381 gcccaccgct ccatctctcc agctgacccc aagctggcac tcacgggtgg gcaggctcag1441 acaggcccag ctccaccaag tgcacttgaa gccggaatgc aagacatccg atggtatact1501 tactcgaacc cgtccttttc acaacagccg cgggatccgc tttctttggc tgactgctca1561 gagtcttccc ttttcctgtg accccattag acgccatggg gggcttttta cccttgagct1621 gttgaaataa acatataaga acattaaaaa taaacacaaa gtcaaacaaa aaaaaaaaaa1681 aaaaa<210>30<211>1421<212>DNA<213>Homo sapiens<400>301 ctaaaccttc acccctgagc acgctcagtg agactggtca tgcaagcatt tacagtgcca61 tgctcctcaa gccgattttt tcttgtagaa atgttgccct atttgtcttc tccaatgtat
121 ggtatgttat tttattttat tattttattt tattttattt tattttatcg agggggggta181 cgatacctgc catttaagaa aatgaataga aaattttaaa acccgagaaa tgggggaaaa241 aaaatcagtg cacaagaatt gggctggtta ggcccagcac cacactgaag tgggctcagt301 ggtttttgga gtgaagaagc cttactccct gcacattccc tcatgctccc acacaagtcc361 agcaatggaa atgcttgggt tcctcttgct ttgtcagggg actcaggagt cgaccaaggg421 aaaccatttg gccccgtgag gaatgggcat tgtcagtatc cgtcctgaac ggggcctagt481 caggaagcgg tctagaagtg tacggtcacg gtcgcctcat gaaagtgtgt agcaggtggc541 tctcaggaaa aataccaagt ctggatcatc catgtggcag ctttgcatag ggagaggata601 gctccgaact ggaactgaac tgccttctct gcacgcttga ccaaagcagt gatgagggcg661 gccagtacct gcggtgtgcg tggtaggttt aaagaaaagg gaatgttttc tgctgagtgt721 ttcctttgtc cttgggctgc tcgagctgga cagtaggtaa ccactgtttt caaggaccag781 cccaatttct ctggcttggt tcggagttcg tttcatccct agctgtgagt gccttttggt841 ctggaaagtt ggcttgtctc ataataccca cagctaggac attctctctg taattatgaa901 ttgtccttgt tttacattaa aagagaatgt ctttgatcac tagagtctgt cggtgttgga961 ttatttccac tgtgagattc ttaaaacttt tttgcttcat aataataaaa caactcatgt1021 tagagaccct ttcaacatga aaggtttgta gttgagacat tacatatatt ttattgttta1081 taataaaaat catctataca aaagaagtcc tgggtgttaa tattttgcac aagatctgtt1141 ttccatgatg tgttgacatc tacaatttca ctaactgttg acgttatttt ctattgagat1201 tctggagcct agggagctat gtgttctttt tgttcatttc gttcttactt ccctgaagca1261 agagactata tggccttcag tgcaaagact tcagaccaat tctttgtatt acacttggtt1321 gcctcttggc tatataactt ctgagtgcaa atcattgaac actttaacga agtattgtag1381 agaataaatc ataatggata aaaaaaaaaa aaaaaaaaaa a
權(quán)利要求
1.一類人類肝臟相關(guān)基因，其包括以下序列的基因(a)SEQ ID No.1～SEQ ID No.30所示的序列；(b)SEQ ID No.1～SEQ ID No.30所示的序列中每條序列的互補(bǔ)序列；(c)與SEQID No.1～SEQ ID No.30所示的序列中每條序列有至少70％同源性的序列，及(d)上述(a)～(c)中一條或數(shù)條的組合。
2.根據(jù)權(quán)利要求1所述的一類人類肝臟相關(guān)基因，其特征在于所述人類肝臟相關(guān)基因包括具有SEQ ID No.1～SEQ ID No.30所示序列的基因。
3.一種探針分子，其特征在于所述的探針分子含有權(quán)利要求1中所述的序列中約8-100個(gè)連續(xù)的核苷酸。
全文摘要
本發(fā)明公開了一類人類肝臟相關(guān)基因。本發(fā)明的人類肝臟相關(guān)基因與一些肝臟疾病相關(guān)，在研究肝臟疾病的致病機(jī)理以及開發(fā)治療肝臟疾病的藥物中發(fā)揮重要作用。
文檔編號(hào)C07H21/00GK1970756SQ20051011059
公開日2007年5月30日 申請(qǐng)日期2005年11月22日 優(yōu)先權(quán)日2005年11月22日
發(fā)明者黃健, 韓澤廣 申請(qǐng)人:上海人類基因組研究中心